{"id":104703,"date":"2020-04-03T13:03:36","date_gmt":"2020-04-03T20:03:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/04\/researchers-determine-how-the-p53-protein-can-lead-cancer-cells-to-their-death"},"modified":"2020-04-03T13:03:36","modified_gmt":"2020-04-03T20:03:36","slug":"researchers-determine-how-the-p53-protein-can-lead-cancer-cells-to-their-death","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/04\/researchers-determine-how-the-p53-protein-can-lead-cancer-cells-to-their-death","title":{"rendered":"Researchers determine how the p53 protein can lead cancer cells to their death"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-determine-how-the-p53-protein-can-lead-cancer-cells-to-their-death.jpg\"><\/a><\/p>\n<p>There is an ongoing battle between cancer cells and p53, the protein known as \u201cthe guardian of the genome,\u201d and a study conducted at the University of Trento has identified a number of factors that influence the outcome of this battle and therefore the effectiveness of cancer treatments.<\/p>\n<p>Scientists explore two therapeutic <a href=\"https:\/\/medicalxpress.com\/tags\/cancer\/\" rel=\"tag\" class=\"\">cancer<\/a> treatment scenarios: In one scenario, <a href=\"https:\/\/medicalxpress.com\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a> stop proliferating; in the other, their death rate increases. Both of these outcomes are regulated the protein p53. Based on the new findings, a specific factor, a protein known as DHX30, determines how p53 can lead cancer cells to their death. That is the conclusion reached by a team of researchers of the University of Trento, who focused on a new molecular mechanism that works like a switch.<\/p>\n<p>Erik Dassi, member of the research team, said, \u201cWhen cancer cells are treated with a certain drug, it is the action of this switch (DHX30) that makes them to go toward cell <a href=\"https:\/\/medicalxpress.com\/tags\/death\/\" rel=\"tag\" class=\"\">death<\/a> and not in the direction of cell cycle arrest.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>There is an ongoing battle between cancer cells and p53, the protein known as \u201cthe guardian of the genome,\u201d and a study conducted at the University of Trento has identified a number of factors that influence the outcome of this battle and therefore the effectiveness of cancer treatments. Scientists explore two therapeutic cancer treatment scenarios: [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-104703","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=104703"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104703\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=104703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=104703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=104703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}