{"id":104228,"date":"2020-03-24T19:22:32","date_gmt":"2020-03-25T02:22:32","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/03\/sars-cov-2-cell-entry-depends-on-ace2-and-tmprss2-and-is-blocked-by-a-clinically-proven-protease-inhibitor"},"modified":"2020-03-24T19:22:32","modified_gmt":"2020-03-25T02:22:32","slug":"sars-cov-2-cell-entry-depends-on-ace2-and-tmprss2-and-is-blocked-by-a-clinically-proven-protease-inhibitor","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/03\/sars-cov-2-cell-entry-depends-on-ace2-and-tmprss2-and-is-blocked-by-a-clinically-proven-protease-inhibitor","title":{"rendered":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/sars-cov-2-cell-entry-depends-on-ace2-and-tmprss2-and-is-blocked-by-a-clinically-proven-protease-inhibitor.jpg\"><\/a><\/p>\n<p>SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry.<\/p>\n<p>The spike protein of SARS-CoV-2 is primed by TMPRSS2.<\/p>\n<p>Antibodies against SARS-CoV spike may offer some protection against SARS-CoV-2.<\/p>\n<hr>\n<p>The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and TMPRSS2 and can be blocked by a clinically proven protease inhibitor. These findings might help to establish options for prevention and treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry. The spike protein of SARS-CoV-2 is primed by TMPRSS2. Antibodies against SARS-CoV spike may offer some protection against SARS-CoV-2. The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and TMPRSS2 and can [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-104228","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=104228"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104228\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=104228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=104228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=104228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}