{"id":104070,"date":"2020-03-21T07:02:47","date_gmt":"2020-03-21T14:02:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/03\/combined-action-of-type-i-and-type-iii-interferon-restricts-initial-replication-of-severe-acute-respiratory-syndrome-coronavirus-in-the-lung-but-fails-to-inhibit-systemic-virus-spread"},"modified":"2020-03-21T07:02:47","modified_gmt":"2020-03-21T14:02:47","slug":"combined-action-of-type-i-and-type-iii-interferon-restricts-initial-replication-of-severe-acute-respiratory-syndrome-coronavirus-in-the-lung-but-fails-to-inhibit-systemic-virus-spread","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/03\/combined-action-of-type-i-and-type-iii-interferon-restricts-initial-replication-of-severe-acute-respiratory-syndrome-coronavirus-in-the-lung-but-fails-to-inhibit-systemic-virus-spread","title":{"rendered":"Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/combined-action-of-type-i-and-type-iii-interferon-restricts-initial-replication-of-severe-acute-respiratory-syndrome-coronavirus-in-the-lung-but-fails-to-inhibit-systemic-virus-spread.png\"><\/a><\/p>\n<p>STAT1-deficient mice are more susceptible to infection with severe acute respiratory syndrome coronavirus (SARS-CoV) than type I interferon (IFN) receptor-deficient mice. We used mice lacking functional receptors for both type I and type III IFN (double knockout, dKO) to evaluate the possibility that type III IFN plays a decisive role in SARS-CoV protection. We found that viral peak titres in lungs of dKO and STAT1-deficient mice were similar, but significantly higher than in wild-type mice. The kinetics of viral clearance from the lung were also comparable in dKO and STAT1-deficient mice. Surprisingly, however, infected dKO mice remained healthy, whereas infected STAT1-deficient mice developed liver pathology and eventually succumbed to neurological disease. Our data suggest that the failure of STAT1-deficient mice to control initial SARS-CoV replication efficiently in the lung is due to impaired type I and type III IFN signalling, whereas the failure to control subsequent systemic viral spread is due to unrelated defects in STAT1-deficient mice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STAT1-deficient mice are more susceptible to infection with severe acute respiratory syndrome coronavirus (SARS-CoV) than type I interferon (IFN) receptor-deficient mice. We used mice lacking functional receptors for both type I and type III IFN (double knockout, dKO) to evaluate the possibility that type III IFN plays a decisive role in SARS-CoV protection. We found [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-104070","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=104070"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/104070\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=104070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=104070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=104070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}