{"id":102165,"date":"2020-02-10T14:03:09","date_gmt":"2020-02-10T22:03:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/02\/osteoarthritis-reversed-in-rats-with-experimental-drug-combo"},"modified":"2020-02-10T14:03:09","modified_gmt":"2020-02-10T22:03:09","slug":"osteoarthritis-reversed-in-rats-with-experimental-drug-combo","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/02\/osteoarthritis-reversed-in-rats-with-experimental-drug-combo","title":{"rendered":"Osteoarthritis reversed in rats with experimental drug combo"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/osteoarthritis-reversed-in-rats-with-experimental-drug-combo2.jpg\"><\/a><\/p>\n<p>Osteoarthritis is one of the most common ailments of an aging population, but there aren\u2019t many treatment options besides taking pain killers or getting a full joint replacement. Now, researchers at the Salk Institute have found that a combination of two experimental drugs appears to reverse the symptoms of the disorder, with successful tests conducted in rats and in human cells in the lab.<\/p>\n<p>As we age, our bodies gradually lose the ability to repair damage as fast as it needs to. That means that tissues subjected to high-intensity long-term use, such as cartilage in joints, are especially prone to wearing out. That manifests itself in the common condition of osteoarthritis, resulting in pain when that joint moves.<\/p>\n<p>In the past, two molecules have been identified as having decent potential for treating the disease \u2013 alpha-KLOTHO (\u03b1KLOTHO) and TGF beta receptor 2 (TGF\u03b2R2). Previous tests only showed moderate success, so the researchers on the new study decided to see if they fared any better when used together.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Osteoarthritis is one of the most common ailments of an aging population, but there aren\u2019t many treatment options besides taking pain killers or getting a full joint replacement. Now, researchers at the Salk Institute have found that a combination of two experimental drugs appears to reverse the symptoms of the disorder, with successful tests conducted [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-102165","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/102165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=102165"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/102165\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=102165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=102165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=102165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}