{"id":101472,"date":"2020-01-27T22:12:06","date_gmt":"2020-01-28T06:12:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/01\/mutations-in-donors-stem-cells-may-cause-problems-for-cancer-patients"},"modified":"2020-01-27T22:12:06","modified_gmt":"2020-01-28T06:12:06","slug":"mutations-in-donors-stem-cells-may-cause-problems-for-cancer-patients","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/01\/mutations-in-donors-stem-cells-may-cause-problems-for-cancer-patients","title":{"rendered":"Mutations in donors\u2019 stem cells may cause problems for cancer patients"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mutations-in-donors-stem-cells-may-cause-problems-for-cancer-patients2.jpg\"><\/a><\/p>\n<p>A new study from Washington University School of Medicine in St. Louis suggests that bone marrow \u2014 or blood stem cells \u2014 from healthy donors can harbor extremely rare mutations that can cause health problems for the cancer patients who receive them.<\/p>\n<hr>\n<p>A stem cell transplant \u2014 also called a bone marrow transplant \u2014 is a common treatment for blood cancers, such as acute myeloid leukemia (AML). Such treatment can cure blood cancers but also can lead to life-threatening complications, including heart problems and graft-versus-host disease, in which new immune cells from the donor attack a patient\u2019s healthy tissues.<\/p>\n<p>A new study from Washington University School of Medicine in St. Louis suggests that extremely rare, harmful genetic mutations present in healthy donors\u2019 stem cells \u2014 though not causing health problems in the donors \u2014 may be passed on to cancer patients receiving stem cell transplants. The intense chemo- and radiation therapy prior to transplant and the immunosuppression given after allow cells with these rare mutations the opportunity to quickly replicate, potentially creating health problems for the patients who receive them, suggests the research, published Jan. 15 in the journal Science Translational Medicine.<\/p>\n<p>Among the concerns are heart damage, graft-versus-host disease and possible new leukemias.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from Washington University School of Medicine in St. Louis suggests that bone marrow \u2014 or blood stem cells \u2014 from healthy donors can harbor extremely rare mutations that can cause health problems for the cancer patients who receive them. A stem cell transplant \u2014 also called a bone marrow transplant \u2014 is [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-101472","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/101472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=101472"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/101472\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=101472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=101472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=101472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}