{"id":100484,"date":"2020-01-04T12:43:34","date_gmt":"2020-01-04T20:43:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2020\/01\/3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery"},"modified":"2020-01-04T12:43:34","modified_gmt":"2020-01-04T20:43:34","slug":"3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2020\/01\/3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery","title":{"rendered":"3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/3d-printed-controlled-release-tritherapeutic-tablet-matrix-for-advanced-anti-hiv-1-drug-delivery.jpg\"><\/a><\/p>\n<p>A 3D-Bioplotter\u00ae was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/efavirenz\" title=\"Learn more about Efavirenz from ScienceDirect's AI-generated Topic Pages\">efavirenz<\/a> (EFV), <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/tenofovir\" title=\"Learn more about Tenofovir from ScienceDirect's AI-generated Topic Pages\">tenofovir<\/a> disoproxil fumarate (TDF) and <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/emtricitabine\" title=\"Learn more about Emtricitabine from ScienceDirect's AI-generated Topic Pages\">emtricitabine<\/a> (FTC).<\/p>\n<p>Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. <em>In vitro<\/em> drug release studies were conducted in biorelevant media followed by <em>in vivo<\/em> study in the <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/yorkshire-pig\" title=\"Learn more about Yorkshire Pig from ScienceDirect's AI-generated Topic Pages\">large white pigs<\/a>, in comparison with a market formulation, Atripla\u00ae. <em>In vitro<\/em>-<em>in vivo<\/em> correlation of results was undertaken.<\/p>\n<p>EFV, TDF and FTC were successfully entrapped in the 24-layered rectangular prism-shaped 3DP FDC with a loading of \u223c12.5 mg\/6.3 mg\/4 mg of EFV\/TDF\/FTC respectively per printed layer. <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/hydrogen\" title=\"Learn more about Hydrogen from ScienceDirect's AI-generated Topic Pages\">Hydrogen<\/a> bonding between the EFV\/TDF\/FTC and HA-PQ10 was detected which was indicative of possible <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/drug-solubility\" title=\"Learn more about Drug Solubility from ScienceDirect's AI-generated Topic Pages\">drug solubility<\/a> enhancement. The overall surface of the tablet exhibited a fibrilla structure and the 90\u00b0 inner pattern was determined to be optimal for 3DP of the FDC. <em>In vitro and in vivo d<\/em> rug release profiles from the 3DP FDC demonstrated that intestinal-targeted and <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/controlled-drug-release\" title=\"Learn more about Controlled Drug Release from ScienceDirect's AI-generated Topic Pages\">controlled drug release<\/a> was achieved.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A 3D-Bioplotter\u00ae was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, efavirenz (EFV), tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC). Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. In vitro drug release studies were conducted in biorelevant [\u2026]<\/p>\n","protected":false},"author":542,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1489,11],"tags":[],"class_list":["post-100484","post","type-post","status-publish","format-standard","hentry","category-3d-printing","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/100484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/542"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=100484"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/100484\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=100484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=100484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=100484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}