{"id":100118,"date":"2019-12-24T19:00:52","date_gmt":"2019-12-25T03:00:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/12\/researchers-identify-immune-suppressing-target-in-glioblastoma"},"modified":"2019-12-24T19:00:52","modified_gmt":"2019-12-25T03:00:52","slug":"researchers-identify-immune-suppressing-target-in-glioblastoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/12\/researchers-identify-immune-suppressing-target-in-glioblastoma","title":{"rendered":"Researchers identify immune-suppressing target in glioblastoma"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-identify-immune-suppressing-target-in-glioblastoma.jpg\"><\/a><\/p>\n<p>Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the almost uniformly lethal brain tumor.<\/p>\n<p>Their findings, reported in <i>Nature Medicine<\/i>, identify macrophages that express high levels of CD73, a surface enzyme that\u2019s a vital piece of an immunosuppressive molecular pathway. The strong presence of the CD73 macrophages was unique to <a href=\"https:\/\/medicalxpress.com\/tags\/glioblastoma\/\" rel=\"tag\" class=\"\">glioblastoma<\/a> among five <a href=\"https:\/\/medicalxpress.com\/tags\/tumor+types\/\" rel=\"tag\" class=\"\">tumor types<\/a> analyzed by the researchers.<\/p>\n<p>\u201cBy studying the immune microenvironments across tumor types, we\u2019ve identified a rational combination therapy for glioblastoma,\u201d says first author Sangeeta Goswami, M.D., Ph.D., assistant professor of Genitourinary Medical Oncology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the almost uniformly lethal brain tumor. Their findings, reported in Nature Medicine, identify macrophages that express high levels of CD73, a [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-100118","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/100118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=100118"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/100118\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=100118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=100118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=100118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}