Lifeboat Foundation

The cost of drug discovery and subsequent development is a massive challenge in the pharmaceutical industry. A typical drug can cost upwards of $2.5 billion and a decade or more to identify and test a new drug candidate[1].

These costs have been increasing steadily over the years, and pharmaceutical manufacturers are constantly seeking ways to improve efficiency to save time and money and speed up research progress.

Automation in the lab is one example; tasks that were traditionally carried out by technicians can now be done by machines. Increasingly sophisticated assays to detect new drug candidates have also helped to slash development time. Now a new ally has arrived to aid drug development – artificial intelligence – and a powerful ally it is.

A team from the Universities of Glasgow, Strathclyde, the West of Scotland and Galway have created a device that sends nano vibrations across mesenchymal stem cells suspended in a collagen gel.

The authors of the paper, published in the Nature Biomedical Engineering journal, found that these tiny vibrations turn the cells into a 3D model of mineralised bone ‘putty’. This putty isn’t quite as hard as bone at this stage. That’s where the body comes in.

“We add the bone putty to an anatomically correct, rigid living scaffold, that we made by 3D printing collagen,” says Matthew Dalby, professor of cell engineering at the University of Glasgow, and one of the lead authors of the paper. “We put lots of cells in the body so it has a chance to integrate this new bone. We tell the cells what to do in the lab, then the body can act as a bioreactor to do the rest.”

Continue reading “How do you grow bone in a lab? Good vibrations” »

Summary: The mitochondrial free radical theory of aging says that if we consume antioxidant supplements, we can repair the damage caused by free radicals. However, this recommendation is contradicted by a large body of evidence which shows that antioxidant supplements are often harmful. Researchers are discovering more effective ways to improve health by clearing our mitochondrial damage caused by free radicals.

Are you killing yourself in a bid to live a longer healthier life?

A growing body of evidence shows that if you take antioxidant supplements, and you are otherwise healthy, then you are wasting your money, and damaging your liver and nervous system.

Continue reading “Are We Killing Ourselves With Antioxidants?” »

Just like the game of Monopoly, which was created to illustrate the operation of laissez faire capitalism, there is always one big winner at the end of the game.

“Wealth concentration drives a vicious, downward cycle, throttling the very engine of wealth creation itself.”

“Because: people with lots of money don’t spend it. They just sit on it, like Smaug in his cave. The more money you have, the less of it you spend every year. If you have $10,000, you might spend it this year. If you have $10 million, you’re not gonna. If you have $1,000, you’re at least somewhat likely to spend it this month.”

Continue reading “Insanely Concentrated Wealth Is Strangling Our Prosperity” »

Now, some of the world’s largest tech companies are taking a cue from biology as they respond to these growing demands. They are rethinking the very nature of computers and are building machines that look more like the human brain, where a central brain stem oversees the nervous system and offloads particular tasks — like hearing and seeing — to the surrounding cortex.

New technologies are testing the limits of computer semiconductors. To deal with that, researchers have gone looking for ideas from nature.

Two-factor authentication by SMS? More like SOS

Once again, it’s been demonstrated that vulnerabilities in cellphone networks can be exploited to intercept one-time two-factor authentication tokens in text messages.

A patch that would have prevented the devastating Equifax breach had been available for months. There’s no excuse for that.

Summary: A new report on mitochondria and cancer shows how our mitochondria help our cancers to grow. With its 37 genes, mitochondria are an attractive druggable target and researchers are looking it as an angle to develop powerful cancer cures. Cover Photo: FatCamera – iStock/Getty Images.

Scientists believe the cure for cancer lies within our mitochondria.

Once considered an academic backwater, researchers suddenly have a renewed interest in the metabolism of cancer cells and are focusing on the lowly mitochondrion. New research shows that the mitochondria within our bodies bend over backward to help cancer cells grow. Scientists are publishing increasing amounts of evidence showing that cancer-induced changes in our mitochondria contribute to the growth of cancer. As Dr. Dario C Altieri, Head of the Altieri Lab at the Wistar Institute said in a review in the July 2017 British Journal of Cancer.

Continue reading “Can We Stop Mitochondria From Causing Cancer to Grow?” »

Most people don’t realize that all human beings have two sets of DNA in their bodies, the DNA inside our chromosomes, and a foreign DNA inside our mitochondria, that our ancestors stole from bacteria over a billion years ago.

Look into any of your cells, and you’ll see mysterious foreign DNA lurking inside your mitochondria, the tiny organelles that litter your cells. Recently, mitochondria have come under a growing scientific spotlight; scientists increasingly believe they play a central role in many, if not most, human illnesses. Mitochondria are the powerhouses of the cell, and when they falter, our cells lose power, just as a flashlight dims when its batteries weaken. Recently, researchers have linked mitochondria to an array of metabolic and age-related maladies, including autism, type 2 diabetes, cancer, Alzheimer’s, Parkinson’s, and cardiovascular disease.

While our mitochondria did not come from another planet, they might as well have. Peer through a microscope, and you’ll swear that tiny aliens have invaded your cells. You are partially correct. Mitochondria appear out of place compared to the other structures within the cell. Something ‘alien’ has invaded our cells, eons ago, but it came from primordial bacteria, a distinctly terrestrial source.