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Dec 9, 2023

Genetic mutations that promote reproduction tend to shorten human lifespan, study shows

Posted by in categories: biotech/medical, genetics, life extension

A University of Michigan-led study based on a review of genetic and health information from more than 276,000 people finds strong support for a decades-old evolutionary theory that sought to explain aging and senescence.

In 1957, evolutionary biologist George Williams proposed that genetic mutations that contribute to aging could be favored by natural selection if they are advantageous early in life in promoting earlier reproduction or the production of more offspring. Williams was an assistant professor at Michigan State University at the time.

Williams’ idea, now known as the antagonistic pleiotropy theory of aging, remains the prevailing evolutionary explanation of senescence, the process of becoming old or aging. While the theory is supported by individual case studies, it has lacked unambiguous genome-wide evidence.

Dec 9, 2023

How a pathogenic bacterium uses molecular mimicry to compromise a cell’s protein building factory

Posted by in category: biotech/medical

The central dogma of molecular biology postulates that the information packets encoded within the molecules of deoxyribonucleic acid (DNA) are first transcribed into molecules of messenger ribonucleic acids (mRNAs), and then subsequently translated/decoded to generate molecules called proteins.

Proteins are essential biomolecules that are composed of multiple smaller subunits called amino acids. These amino acids are stitched together via peptide bonds and contribute to the shape, size and charge distribution that the protein, as a sum of its amino acid parts, eventually exhibits.

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Dec 9, 2023

Team reviews phosphine ligand-induced structural transformation of metal nanoclusters

Posted by in categories: biotech/medical, nanotechnology

A team of researchers has reviewed a unique method for reforming the structures of ultra-small nanomaterials. These nanomaterials, called metal nanoclusters, bridge the gap between the metal atom and the bulk metal, making them highly useful in both basic and applied research. Metal nanoclusters have the potential for wide-ranging applications in the biomedical fields.

The team’s review paper is published in the journal Polyoxometalates.

The team investigated the phosphine-LEIST reaction. This method shows advantages in nanoclusters’ structural modification and property modulation. “The method we reviewed is able to modulate the atomically precise structure of metal nanoclusters and regulate their corresponding performance,” said Man-Bo Li, a professor at Anhui University, China.

Dec 9, 2023

Mixtral: French start-up Mistral releases what is essentially a small GPT-4

Posted by in category: robotics/AI

French startup Mistral AI has released its new language model Mixtral 8x7B via a torrent link. Mixtral is a mixture-of-experts model, following an architecture that OpenAI is rumored to be using for GPT-4, but on a much larger scale.

There are no benchmarks, blog posts, or articles about the model yet, but Mistral-7B — the first version of Mistral AI — generally performed very well and was quickly adopted by the open-source community. Mistral is thought to have used the MegaBlocks MoE library for training. The Paris-based company was recently valued at nearly $2 billion.

Dec 9, 2023

Prioritizing Brain Health: Preventing Cognitive Decline

Posted by in categories: life extension, neuroscience

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficienh #Wellness #DavidSinclair #Longevity #BrainHealth #Healthspan

Dec 9, 2023

Stressors for Longevity: Exercise, Heat, Cold & More

Posted by in categories: biotech/medical, life extension

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.

Dec 9, 2023

Unlocking the Secrets of Lifespan with Dr. David Sinclair

Posted by in categories: genetics, life extension

Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research.

Dec 9, 2023

What to Eat & When to Eat for Longevity

Posted by in categories: food, life extension

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a “low energy state,” which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. #Food #DavidSinclair #Longevity

Dec 9, 2023

How to Not Die

Posted by in categories: genetics, life extension

Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.

Dec 9, 2023

Researchers quantify the onset of turbulence in a pipe bent back on itself

Posted by in category: futurism

How much stress do pipes undergo when a liquid flows through them, and how does it depend on the degree of curvature of the pipe?

Bends in pipes are especially crucial, for example in the aortic arch that connects to the left ventricle of the human heart. Piping systems in industrial plants often include bends of 90 degrees or more, can be helical, and can even have 180-degree bends. Fluid mechanists in Sweden have analyzed in such pipes with a 180-degree bend. Their research is published in the journal Physical Review Fluids.

Bends in pipes are different than their straight sections because, in the curved sections, there are outward centrifugal forces due to the inertia of the liquid inside. That force is balanced by a pressure gradient from the outer wall of the to the inner wall. Because the fluid velocities in an imaginary slice through the pipe will not be equal in the curved section—for example, the velocity near the outer wall of the pipe will be greater than near the inner wall—a secondary pattern, besides the motion through the pipe, is set up perpendicular to the main flow direction.

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