Lifeboat Foundation

Cancer can be triggered by different causes. Melanoma is usually induced by the sun, by dangerous ultraviolet light damage. In the majority of cases, UV damage leaves a unique mutational footprint behind and as a result unstoppable cell proliferation is induced.

UV damage gives rise to point mutations – changes in a single letter of the 3 billion letter human genome. These mutations can interfere with signals that tell cells when to grow and divide and when to stop. Mutations in a protein called BRAF, a major signaling regulator, cause growth signals to be stuck in the “on” position and drive cancer development.

Though scientists have managed to come up with drugs that target and turn off aberrant BRAF signaling, cancer cells are clever. They learn to adapt to these BRAF-inhibitors. Today, many patients respond to cancer treatment very positively at first. However, unfortunately many ultimately develop resistance and metastases.

Continue reading “Cancer not only mutates but evolves other mechanisms to beat drugs” »

COLUMBUS, Ohio — A gravitational wave detector that’s 2.5 miles long isn’t cool. You know what’s cool? A 25-mile-long gravitational wave detector.

That’s the upshot of a series of talks given here Saturday (April 14) at the April meeting of the American Physical Society. The next generation of gravitational wave detectors will peer right up to the outer edge of the observable universe, looking for ripples in the very fabric of space-time, which Einstein predicted would occur when massive objects like black holes collide. But there are still some significant challenges standing in the way of their construction, presenters told the audience.

“The current detectors you might think are very sensitive,” Matthew Evans, a physicist at MIT, told the audience. “And that’s true, but they’re also the least sensitive detectors with which you can [possibly] detect gravitational waves.” [8 Ways You Can See Einstein’s Theory of Relativity in Real Life].

Continue reading “A City-Sized ‘Telescope’ Could Watch Space-Time Ripple 1 Million Times a Year” »

The biotechnology sector’s fastest-growing segment, immuno-oncology, has become the hottest buzzword for investment in Asia.

The field, that uses the body’s own immune system to help fight cancer, has seen two mega acquisitions in the United States in recent months.

And Hong Kong stock exchange is now tuning into its strong future, with Hong Kong Exchanges and Clearing (HKEX) already agreeing to revamp listing rules that will fast track applications by firms linked with the sector to help more innovative drugs and medical devices developers go public as soon as early this summer, and raise much-needed development cash.

Continue reading “Why immuno-therapy is leaving markets abuzz across the world” »

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These photos are quite literally out of this world.

Disruption of the regulator for G protein signaling 14 (RGS14) knockout (KO) in mice extends their lifespan and has multiple beneficial effects related to healthful aging, that is, protection from obesity, as reflected by reduced white adipose tissue, protection against cold exposure, and improved metabolism. The observed beneficial effects were mediated by improved mitochondrial function. But most importantly, the main mechanism responsible for the salutary properties of the RGS14 KO involved an increase in brown adipose tissue (BAT), which was confirmed by surgical BAT removal and transplantation to wild‐type (WT) mice, a surgical simulation of a molecular knockout. This technique reversed the phenotype of the RGS14 KO and WT, resulting in loss of the improved metabolism and protection against cold exposure in RGS14 KO and conferring this protection to the WT BAT recipients. Another mechanism mediating the salutary features in the RGS14 KO was increased SIRT3. This mechanism was confirmed in the RGS14 X SIRT3 double KO, which no longer demonstrated improved metabolism and protection against cold exposure. Loss of function of the Caenorhabditis elegans RGS‐14 homolog confirmed the evolutionary conservation of this mechanism. Thus, disruption of RGS14 is a model of healthful aging, as it not only enhances lifespan, but also protects against obesity and cold exposure and improves metabolism with a key mechanism of increased BAT, which, when removed, eliminates the features of healthful aging.

The ending of the new Netflix ‘Lost In Space’ reboot puts the Robinson family in far out space. But, the binary star system they see could be a real place in the Milky Way. It bears a strong resemblance to VFTS 352, an actual binary star in the Large Magellanic Cloud in our own milky way galaxy.

Processors with artificial intelligence will spread from today’s top-end phones to cars, PCs, security cameras, smart speakers and mainstream phones.

A clinical-grade retinal implant made of human #embryonic stem cell (#hESC)–derived RPE grown on a synthetic substrate has been developed by Kashani and team. The progressive binding disease that causes loss of the retinal pigment epithelium (RPE) of the eye is known as #Non-neovascular age-related macular degeneration (#NNAMD). Currently there are only preventative measures that can be taken but there is no effective treatment. Some preventative measures include quitting smoking and the use of specific nutritional supplements to reduce the risk of developing NNAMD. The implant was not only shown to be safe in a first-in-human phase 1 clinical trial in five patients with advanced NNAMD, but also well tolerated. Plausible therapeutic effects on visual clarity were reported in the experimental results, indicating that this approach may be beneficial for treating retinal disorders involving #RPE loss.