Lifeboat Foundation

A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1].

Study abstract

Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia (HPP) and early-onset bone dysplasia, suggesting that this gene is a key factor in human bone development. However, how and where Alpl acts in bone ageing is largely unknown. Here, we determined that ablation of Alpl induces prototypical premature bone ageing characteristics, including bone mass loss and marrow fat gain coupled with elevated expression of p16INK4A (p16) and p53 due to senescence and impaired differentiation in mesenchymal stem cells (MSCs). Mechanistically, Alpl deficiency in MSCs enhances ATP release and reduces ATP hydrolysis. Then, the excessive extracellular ATP is, in turn, internalized by MSCs and causes an elevation in the intracellular ATP level, which consequently inactivates the AMPKα pathway and contributes to the cell fate switch of MSCs.

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The alliance urges the European Commission to implement an AI strategy for the EU as a whole along the lines of the US National AI Research and Development Plan that was released in late 2016, and China’s Next Generation AI Development Plan that was issued the following year.

More than 2,000 researchers join forces to urge EU to help continent build ‘Google-style’ infrastructure as counterweight to the two leading AI players.

Astronomers found something not predicted by current theory when they took a closer look at the emissions from a neutron star with a very strong magnetic field.

British set designer Es Devlin has been chosen to create the UK Pavilion at the Dubai Expo 2020, with a performative structure that will use artificial intelligence to write poems.

Called the Poem Pavilion, the structure will feature an illuminated “message to space” made up of numerous AI-generated poems, which the Expo’s anticipated 25 million visitors will be invited to contribute to.

The 20-metre-high, cone-shaped pavilion will be made up of rows of protruding slats that extend outwards from one central point to form a circular facade. Poems lit up in LEDs will scroll across the facade.

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Microsoft and Shell are teaming up to try and make pumping gas safer by developing AI capable of alerting employees when an idiot smokes at the pump.

A new theory proposes that the quantum properties of an object extend into an “atmosphere” that surrounds the material.

Illuminating mathematics, physics, biology and computer science research through public service journalism.

September 27 is World Tourism Day, which has been celebrated each year by the United Nations World Tourism Organization since 1980. The theme this year is “Tourism and the Digital Transformation,” as digital technology has permeated the tourism industry.

Virtual reality, augmented reality, artificial intelligence, Internet-plus — these terms have gradually become familiar to people travelling in China, as the country is heading to its tourism industry 3.0. A wide range of cutting-edge technologies have been innovatively applied in almost every part of China’s tourism industry.

The new digital communications policy (NDCP) 2018, approved by the Cabinet on Wednesday, looks too good to believe. It has promised to create an additional four million jobs in five years and reskill another one million people in new-age skills and sectors such as 5G LTE and artificial intelligence. Six lakh villages will be connected which will eventually lead to creating jobs and several earning avenues such as managing WiFi hotspots and laying optical fibre, among others. The policy will give an impetus to the job market.

NDCP is bound to create a massive infrastructure and help the debt-ridden telecom sector emerge from its current turbulence. The policy document envisages the reduction in levies and ease of doing business, and this will help restore the financial health of the long-bleeding sector. The focus will be on the proliferation of telecom services and facilitating low-cost financing. The government’s ambitious plan of Digital India will get a booster shot. Thanks to the promise of 50 Mbps speed in the broadband connection, the consumer will be the ultimate beneficiary.

Plans are afoot to reform the licensing and regulatory regime to facilitate investments and innovation, besides promoting ease of doing business. The success of the policy will depend on the execution of the policy.

Continue reading “DNA Money Edit: Telecom sector awaits a turnaround” »