Lifeboat Foundation

Neurons, specialized cells that transmit nerve impulses, have long been known to be a vital element for the functioning of the human brain. Over the past century, however, neuroscience research has given rise to the false belief that neurons are the only cells that can process and learn information. This misconception or ‘neurocomputing dogma’ is far from true.

An astrocyte is a different type of brain cell that has recently been found to do a lot more than merely fill up spaces between neurons, as researchers believed for over a century. Studies are finding that these cells also play key roles in brain functions, including learning and central pattern generation (CPG), which is the basis for critical rhythmic behaviors such as breathing and walking.

Although astrocytes are now known to underlie numerous brain functions, most existing computer systems inspired by the human brain only target the structure and function of neurons. Aware of this gap in existing literature, researchers at Rutgers University are developing brain-inspired algorithms that also account for and replicate the functions of astrocytes. In a paper pre-published on arXiv and set to be presented at the ICONS 2020 Conference in July, they introduce a neuromorphic central pattern generator (CPG) modulated by artificial astrocytes that successfully entrained several rhythmic walking behaviors in their in-house robots.

A federal court on Friday upheld a regulation that removes barriers to electric grid-level batteries that store electricity.

The regulation in question requires that grid operators treat storage similar to the way power plants are treated. It was promulgated in 2018 by the Federal Energy Regulatory Commission (FERC).

A SARS-CoV-2 variant has taken over the world, but it’s not clear whether the coronavirus mutation is highly transmissible or just lucky.

The robot seen here can work almost 24–7, carrying out experiments by itself. The automated scientist – the first of its kind – can make its own decisions about which chemistry experiments to perform next, and has already discovered a new catalyst.

With humanoid dimensions, and working in a standard laboratory, it uses instruments much like a human does. Unlike a real person, however, this 400 kg robot has infinite patience, and works for 21.5 hours each day, pausing only to recharge its battery.

This new technology – reported in the journal Nature and featured on the front cover – is designed to tackle problems of a scale and complexity that are currently beyond our grasp. New drug formulations could be autonomously discovered, for example, by searching vast and unexplored chemical spaces.

The solution was to split the protein into two harmless halves. Liu’s team, led by graduate student Beverly Mok, used 3D imaging data from the Mougous lab to work out how to divide the protein into two pieces. Each piece did nothing on its own, but when reunited, they reconstituted the protein’s full activity. The team fused each deaminase half to customizable DNA-targeting proteins that did not require guide RNAs. Those proteins bound to specific stretches of DNA, bringing the two halves of the deaminase together. That let the molecule regain its function and work as a precision gene editor—but only once it was correctly positioned.

Liu’s team used the technology to make precise changes to specific mitochondrial genes. Then, Mootha’s lab, which focuses on mitochondrial biology, ran tests to see whether the edits had the intended effect. “You could imagine that if you’re introducing editing machinery into the mitochondria, you might accidentally cause some sort of a catastrophe,” Mootha said. “But it was very clean.” The entire mitochondrion functioned well, except for the one part the scientists intentionally edited, he explained.

This mitochondrial base editor is just the beginning, Mougous suggested. It can change one of the four DNA letters into another. He hopes to find additional deaminases that he and Liu can develop into editors able to make other mitochondrial DNA alterations. Such tools could enable new strategies for treating mitochondrial diseases, as well as help scientists to model diseases and aid in drug testing. “The ability to precisely install or correct pathogenic mutations could accelerate the modeling of diseases caused by mtDNA mutations, facilitate preclinical drug candidate testing, and potentially enable therapeutic approaches that directly correct pathogenic mtDNA mutations,” the authors noted. “Bacterial genomes contain various uncharacterized deaminases, raising the possibility that some may possess unique activities that enable new genome-editing capabilities.”

Graphene is insanely useful, but very difficult to produce — until now.

Designed with former elite military operatives, the Ceramic Clothing System from Vollebak is as hardcore as any extreme conditions you might encounter. It boasts a three-part layering system that is the first in the world to use ceramic technology to make their T-Shirt, Baselayer, and Midlayer. All three are abrasion resistant yet soft, stretchy, breathable and as comfy as your favorite sports clothing. And each Ceramic layer is embedded with over 100,000 particles that can’t be scratched off or washed away.

Scientists have made a battery that can be directly charged in sunlight without needing an external solar panel. Clever design of the battery electrodes facilitates photo-rechargeable zinc-ion batteries that could find applications as cheap devices for off-grid solar farms.

Solar energy is often stored in rechargeable batteries for later use. Currently, this process requires separate solar cells to harvest the energy, and batteries to store it. Now, a team led by Michael De Volder from the University of Cambridge in the UK has engineered a battery cathode that can take the place of the solar cell and recharge the battery without requring an external energy harvester.

CAPE CANAVERAL, Fla. (AP) — A newly discovered comet is streaking past Earth, providing a stunning nighttime show after buzzing the sun and expanding its tail.

Comet Neowise swept within Mercury’s orbit a week ago. Its close proximity to the sun caused dust and gas to burn off its surface and create an even bigger debris tail. Now the comet is headed our way, with closest approach in two weeks.

NASA’s Neowise infrared space telescope discovered the comet in March.