Lifeboat Foundation

Jacques Cousteau’s grandson is pushing for the construction of a real-life Sealab 2021. The proposed undersea laboratory is so foreign to our idea of marine studies that it’s being likened to a space station that’s also under the ocean.

The station is named Proteus, not for the changing nature of matter (like a new uncuttable material with the same name), but for the shepherd of the sea. By placing a station 60 feet underwater around the Caribbean island of Curacao, sponsoring Northeastern University says it can reduce divers’ high amount of overhead time and reduce the danger of nitrogen-induced health effects.

Cholangiocarcinoma may not be a household word unless, of course, you happen to be a pathologist studying hepatic cancers. Still, it does affect a fair number of individuals, typically over the age of 50. Cholangiocarcinoma is a group of cancers that begin in the bile ducts, which carry digestive fluid to the small intestine. Cholangiocarcinomas are classified by their location in relation to the liver and typically grouped in with other types of liver cancer. Now, a team of investigators at the Spanish National Cardiovascular Research Centre (CNIC) believe they have uncovered a mechanism that controls the development of intrahepatic cholangiocarcinoma.

Findings from the new study—published recently in PNAS through an article entitled “JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma”—identified a protein that, when blocked, dramatically reduces the impact and progression of the cancer.

Spanish scientists have designed an animal model to study the development of liver cancer caused by bile acids, whcih could speed drug discovery.

Continue reading “Novel Liver Cancer Mechanism Controls Development of Disease” »

What changed things for Germany? A handful of prominent scientists communicating regularly and openly with the public. (via CNBC)…and a leader who is a scientist.

Germany, like many other countries, had a contingent of people who fought lockdowns and argued that Covid-19 was a hoax. But it also had a handful of prominent scientists communicating regularly and openly with the public. That played a huge role in drowning out rumors and misinformation, locals tell CNBC.

“We have a great educational system and everyone has access to it,” said Dennis Traub, a tech worker in Hamburg, Germany. “So I believe that many people and the majority listened to both sides and one of those sides sounded much more reasonable.”

Continue reading “Germany’s coronavirus response is a master class in science communication” »

A team of marine ecologists from Oregon State University has described the formation and development of a new methane seep — a location where methane escapes from an underground reservoir and into the ocean — in the Ross Sea, the High Antarctic.

Summary: Depending on the network state, certain neurons in the primary somatosensory cortex can be more or less excitable, which shapes stimulus processing in the brain.

Source: Max Planck Institute

Rustling leaves, light rain at the window, a quietly ticking clock – muffled sounds, just above the threshold of hearing. One moment we perceive them, the next we don’t, even if we, or the sounds, don’t seem to change. Many studies have shown that we never process an incoming stimulus, be it a sound, an image, or a touch, in the same way. This is true, even if the stimulus is exactly the same. This occurs because the impact a stimulus makes, on the brain regions that process it, depends on the momentary state of the networks those brain regions belong to. However, the factors that influence and underlie the constantly fluctuating momentary state of the networks and whether these states are random or follow a rhythm, was previously unknown.

In this post, we will cover the initial experience of using mapperidea.

Mapperidea CLI requires Node installed into your machine, as well as the nvm utility, so check the requisites first:

The original creator and inventor of that development concept and methodology: Clovis Wichoski, currently Skalena’s CTO. That solution has more than 15 years. In 2014, Clovis met Edgar Silva, back on that time working for WSO2 as the Latin American Head, and working together for a customer with a low budget and very short time to get the project done, they had decided to use bacalhau(codfish) the first way that Edgar had named that project on that time. In 2018, Edgar invited Clovis to be part of a new project in 2019 (Skalena), where one of the goals was to make mapperidea a real product, and not only in Brazil, but helping the whole world in how to develop software better, faster and to be a key enabler for a pragmatic and definitive Digital Transformation.

Researchers have developed an automated machine learning system they say can detect social media posts involved in coordinated political influence campaigns—such as Russia’s alleged efforts to sway the results of the 2016 elections in the United States—regardless of platform and based only on the content of the posts.

Read more in Science Advances.

We study how easy it is to distinguish influence operations from organic social media activity by assessing the performance of a platform-agnostic machine learning approach. Our method uses public activity to detect content that is part of coordinated influence operations based on human-interpretable features derived solely from content. We test this method on publicly available Twitter data on Chinese, Russian, and Venezuelan troll activity targeting the United States, as well as the Reddit dataset of Russian influence efforts. To assess how well content-based features distinguish these influence operations from random samples of general and political American users, we train and test classifiers on a monthly basis for each campaign across five prediction tasks. Content-based features perform well across period, country, platform, and prediction task. Industrialized production of influence campaign content leaves a distinctive signal in user-generated content that allows tracking of campaigns from month to month and across different accounts.

Continue reading “Content-based features predict social media influence operations” »

Guest: David Shumaker, USA

Utilizing neurotransmitters as a passport into the brain:

Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successfully delivered amphotericin B (AmB), antisense oligonucleotides (ASOs) against tau, and genome-editing fusion protein (−27)GFP-Cre recombinase into the mouse brain via systemic intravenous administration. We demonstrated that the NT-lipidoid formulation not only facilitates cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. This class of brain delivery lipid formulations holds great potential in the treatment of central nervous system diseases or as a tool to study the brain function.