The novel coronavirus is challenging genome sequencing technology and data processing like never before by.
Claire Jarvis, special to C&EN.
Coronaviruses are enveloped, positive-stranded RNA viruses with a genome of approximately 30 kb. Based on genetic similarities, coronaviruses are classified into three groups. Two group 2 coronaviruses, human coronavirus OC43 (HCoV-OC43) and bovine coronavirus (BCoV), show remarkable antigenic and genetic similarities. In this study, we report the first complete genome sequence (30,738 nucleotides) of the prototype HCoV-OC43 strain (ATCC VR759). Complete genome and open reading frame (ORF) analyses were performed in comparison to the BCoV genome. In the region between the spike and membrane protein genes, a 290-nucleotide deletion is present, corresponding to the absence of BCoV ORFs ns4.9 and ns4.8. Nucleotide and amino acid similarity percentages were determined for the major HCoV-OC43 ORFs and for those of other group 2 coronaviruses. The highest degree of similarity is demonstrated between HCoV-OC43 and BCoV in all ORFs with the exception of the E gene. Molecular clock analysis of the spike gene sequences of BCoV and HCoV-OC43 suggests a relatively recent zoonotic transmission event and dates their most recent common ancestor to around 1890. An evolutionary rate in the order of 4 × 10−4 nucleotide changes per site per year was estimated. This is the first animal-human zoonotic pair of coronaviruses that can be analyzed in order to gain insights into the processes of adaptation of a nonhuman coronavirus to a human host, which is important for understanding the interspecies transmission events that led to the origin of the severe acute respiratory syndrome outbreak.
Coronaviruses are large (120- to 160-nm), roughly spherical particles with a linear, nonsegmented, capped, and polyadenylated positive-sense single-stranded RNA genome that is encapsidated in a helical nucleocapsid. The envelope is derived from intracellular membranes and contains a characteristic crown of widely spaced club-shaped spikes that are 12 to 24 nm long. The genus Coronavirus (International Committee on the Taxonomy of Viruses database [ICTVdb], virus code 03.019.0.1) belongs to the family Coronaviridae in the order Nidovirales (7, 8).
Before the 2002-to-2003 severe acute respiratory syndrome (SARS) epidemic, coronaviruses were somewhat neglected in human medicine, but they have always been of considerable importance in animal health. Coronaviruses infect a variety of livestock, poultry, and companion animals, in whom they can cause serious and often fatal respiratory, enteric, cardiovascular, and neurologic diseases (25). Most of our understanding about the molecular pathogenic properties of coronaviruses has been achieved by the veterinary virology community.
Decades after stumbling upon a stunning coincidence, researchers are close to understanding the link between two seemingly unrelated geometric universes.
The DUNE collaboration has published their first scientific paper based on data collected with the ProtoDUNE single-phase detector located at CERN’s Neutrino Platform. The results show that the detector is performing with greater than 99% efficiency, making it not only the largest, but also the best-performing liquid-argon time projection chamber to date. Scientists now are using their findings to refine their experimental techniques and prepare for the construction of the international Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility, a next-generation neutrino experimental program hosted by the Department of Energy’s Fermilab in the United States.
“These first results are great news for us,” said DUNE co-spokesperson Stefan Söldner-Rembold, professor at the University of Manchester in the UK. “They show that the ProtoDUNE-SP detector works even better than anticipated. Now we are ready for the construction of the first components for the DUNE detector, which will feature detector modules based on this prototype, but 20 times larger.”
DUNE is an ambitious international experiment that will measure the properties of tiny fundamental particles called neutrinos. Neutrinos are the most abundant matter particle in the universe, but because they rarely interact with other particles, they are incredibly difficult to study. There are at least three different types of neutrinos, and, every second, 65 billion of them pass through each square centimeter of Earth. As they travel, they do something peculiar: They change from one type to another. Scientists think that these neutrino oscillations — as well as oscillations involving antimatter neutrinos — could help answer some of the big questions in physics, such as the observed matter-antimatter asymmetry in the universe. DUNE will also look for neutrinos from supernovae and search for rare subatomic processes such as proton decay.
Serena Corr looks at the science behind batteries, discusses why we are hunting for new ones and investigates what tools we use to pave this pathway to discovery.
Watch the Q&A: https://youtu.be/lZjqiR0czLo.
The hunt is on for the next generation of batteries that will power our electric vehicles and help our transition to a renewables-led future. Serena shows how researchers at the Faraday Institution are developing new chemistries and manufacturing processes to deliver safer, cheaper, and longer-lasting batteries and provide higher power or energy densities for electric vehicles.
Continue reading “The Hunt for New Batteries — with Serena Corr” »
This is something straight out of ‘Westworld.’ With a repurposed 3D printer and a container of gelatin, researchers turned an MRI scan of a human heart into a full-size analog. Squeeze it, and it’ll give like the real thing. Slice it open, and you’ll find chambers. The advance might eventually lead to fully-functioning 3D-printed hearts: https://wired.trib.al/7UZPU68
📽️: Eman Mirdamadi, Daniel Shiwarski, Joshua Tashman.
Exciting momentum!! — Home Depot Founder, Bernie Marcus (age 91), and the Adolph Coors Foundation (beer family), putting millions of $$$ into comprehensive integrative health and wellness — Good to see the trend!!
The Marcus Institute of Integrative Health was established in Philadelphia in 2017 by Thomas Jefferson University and Jefferson Health, and a multi-million $$$ grant from the Marcus Foundation (headed by it’s Chairman, Bernie Marcus, Co-Founder of The Home Depot) to expand the research, education and clinical care profile of Jefferson’s integrative medicine program, and to set the international standard of excellence in evidence-based, patient-centered integrative care.
At least humans can still say they are better at something… for now. 😃
What happens if you let a neural network loose on inventing names for monsters in Dungeons and Dragons? Well, it turns out it comes up with some rather ridiculous suggestions.
Research scientist Janelle Shane from Boulder, Colorado previously used a recurrent neural network to come up with some odd spell names for D&D, but this time around she turned her powers of hilarity towards creating new names for monsters.
This portable turbine uses water or wind to charge your devices and is ideal for campers, paddlers, filmmakers, and off-gridders around the world…
