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Jun 7, 2023

Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

Posted by in categories: biotech/medical, chemistry, computing, engineering

Year 2019 😗😁

Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics.

Jun 7, 2023

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids Communications

Posted by in categories: biotech/medical, neuroscience

Year 2021

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Jun 7, 2023

Crocodile found to have made herself pregnant

Posted by in category: futurism

Baby crocodile Jesus 🐊.

Researchers have found the first case of a crocodile who made herself pregnant.

Jun 7, 2023

ChatGPT Maker OpenAI Is Staying Private So It Can Make ‘Strange’ Decisions

Posted by in categories: policy, robotics/AI

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Jun 7, 2023

Is there an infinite universe? According to scientists, our universe has no beginning

Posted by in categories: cosmology, evolution, quantum physics, singularity

The Big Bang, traditionally considered the birth of the universe about 14 billion years ago, is being questioned. Physicist Bruno Bento and his team have proposed compelling research suggesting the universe may have always existed, and the Big Bang may merely be a significant event in its continuous evolution.

Bruno Bento and his colleagues set out to examine what the universe’s inception might have looked like without a Big Bang singularity. They grappled with contradictions arising when comparing accepted theories, particularly those dealing with quantum physics and general relativity. While quantum physics has accurately described three of the four fundamental forces of nature, it struggles to incorporate gravity. On the other hand, general relativity offers a comprehensive explanation of gravity, but falters when dealing with black holes’ centers and the universe’s genesis.

These contentious areas, termed “singularities,” are points in space-time where established physical laws cease to apply. Intriguingly, computations indicate an immense gravitational pull within singularities, even on a minuscule scale.

Jun 7, 2023

Mathematicians end decades-long quest to find elusive ‘vampire einstein’ shape

Posted by in category: mathematics

Researchers have discovered a new 14-sided shape called the Spectre that can be used to tile a surface without ever creating a repeating pattern, ending a decades’ long mathematical hunt.

Jun 7, 2023

Hundreds of ancient, invisible structures discovered near our galaxy’s center

Posted by in category: cosmology

Radio astronomers have discovered hundreds of long, thin structures emanating from our galaxy’s supermassive black hole.

Jun 7, 2023

A Personal Flying Vehicle Prototype Can Fly You at 160 MPH

Posted by in category: transportation

A team of Washington State University (WSU) researchers is working with ZEVA Aero, a Tacoma-based start-up, and testing components to create a single-passenger, electric vertical takeoff and landing (eVTOL) aircraft, taking us one step closer to turning that dream into reality.

Jun 7, 2023

Magnetic trap keeps a superconducting microsphere levitated and stable

Posted by in category: particle physics

It might not look like much, but this tiny levitating particle could be the key to a new generation.

Jun 7, 2023

Airbus has unveiled the aircraft cabin of the future. Take a look at Airspace Cabin Vision 2035+

Posted by in categories: sustainability, transportation

Airbus’ vision for more sustainable aircraft cabins includes lighter, recyclable materials, new catering concepts, and a focus on transparency.

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