Lifeboat Foundation

We cordially invite you to participate in the 5th International Symposium on Frontiers in Molecular Sciences Regulatory Mechanisms of Biological Function and Drug Discovery based on Protein Structure/Function Analysis, to be held in Kyoto, Japan, from August 26 to 29, 2025. The symposium will present outstanding research results that elucidate the molecular mechanisms of biological function and regulation, and it will also facilitate drug design based on molecular biology, biophysical characterization, in vivo environmental homeostasis, organ interactions based on sensory systems, physiome, and AI-assisted analysis of protein structures and functions.

The venue will be the Inamori Hall, Liberal Arts and Science Building and the Kyoto Institute, Library and Archives (Rekisaikan), both affiliated with Kyoto Prefectural University, Kyoto Prefectural University of Medicine and the Kyoto Prefectural Government, located in Kyoto City. The venue is conveniently located approximately 20 minutes by subway or car from Japan Railway (JR) Kyoto Station, which is also easily accessible from Kansai International Airport (KIX) by JR (approximately 1 hour 20 minutes) or limousine bus (approximately 1 hour 30 minutes).

Hip osteoarthritis (HOA), a prevalent condition among those aged 55 years and above, is a significant cause of joint pain and functional impairment and it contributes to the overall burden of chronic pain experienced by the elderly population. While platelet-rich plasma (PRP) and hyaluronic acid (HA) injections have emerged as innovative therapeutic approaches for managing osteoarthritis, their effectiveness in HOA remains a subject of contention. Therefore, the objective of this review was to assess the efficacy of PRP versus HA in terms of pain relief and functional outcomes for the management of HOA. We searched PubMed, Cochrane Library, and Google Scholar databases from 2013 to 2023 to identify pertinent randomized controlled trials (RCTs). A total of seven trials (478 participants) were included. The selected studies underwent quality assessment using the updated Cochrane risk of bias tool. The pain and functional outcomes were examined using measures of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scale, visual analog scale (VAS), and Harris hip score (HHS). In the meta-analysis, standard mean differences (SMDs) along with 95% confidence intervals (CIs) to estimate overall effect magnitudes for continuous outcomes were extracted. Statistical significance was determined using p-values below 0.05. At six months, the PRP group experienced a significantly lower standard mean WOMAC pain score (SMD =-0.38, CI =-0.64 — 0.13; p = 0.03). No significant differences in WOMAC pain scores were noted at one to two months (SMD = 0.09, CI =-0.24, 0.43; p = 0.59), and at 12 months (SMD =-0.85, CI =-1.81, 0.12; p = 0.09). Similarly, for VAS, patients on PRP showed a slight improvement in their VAS scores at six months (SMD =-0.50, CI =-0.89,-0.12; p < 0.01). However, no significant differences in VAS between the PRP groups and the HA groups were observed at one to two months (SMD =-0.22, CI =-0.49, 0.04; p = 0.10) and at 12 months (SMD =-0.22, CI:-0.63, 0.19; p = 0.29). In terms of hip dysfunction, there was no statistically significant standard mean difference in HHS between the PRP and HA groups at six months (SMD = 0.02, CI =-0.40, 0.44; p = 0.93), and at 12 months (SMD =-0.31, CI =-0.32, 0.22; p = 0.73). This review and meta-analysis provide insights into emerging treatments for HOA, especially considering that PRP shows potential benefits and safety for patients with HOA during mid-term follow-up in a 12-month period. Nevertheless, it is necessary to conduct research that includes high-quality designs and larger sample sizes to validate the comparative efficacy of these treatments.

Ice scouring is one of the strongest agents of disturbance in nearshore environments at high latitudes. In depths, less than 20 m, grounding icebergs reshape the soft-sediment seabed by gouging furrows called ice pits. Large amounts of drift algae (up to 5.6 kg/m2) that would otherwise be transported to deeper water accumulate inside these features, representing an underestimated subsidy. Our work documents the distribution and dimensions of ice pits in Fildes Bay, Antarctica, and evaluates their relationship to the biomass and species composition of algae found within them. It also assesses the rates of deposition and advective loss of algae in the pits. The 17 ice pits found in the study area covered only 4.2% of the seabed but contained 98% of drift algal biomass, i.e., 60 times the density (kg/m2) of the surrounding seabed.

💡 LastestPaper.

📚 🔗 https://brnw.ch/21wPhFj.

🧑🏻‍🔬 By Ms. Cloe García Porta, Dr. Kashif Mahfooz, Mr. Joanna Komorowska, Dr. Sara Garcia-Rates and Dr. Susan Greenfield.

Continue reading “A Novel 14mer Peptide Inhibits Autophagic Flux via Selective Activation of the mTORC1 Signalling Pathway: Implications for Alzheimer’s Disease” »

The Kanlaon volcano in the Philippines erupted today (Dec. 9) at 3:03 p.m. local time, spouting an eruption column of up to 1.86 miles (3 kilometers) into the sky and triggering the evacuation of 87,000 people.

Nobel laureate Daron Acemoglu has long studied technology-driven growth. Here’s how he’s thinking about AI’s effect on the economy.

In a groundbreaking development, researchers at the Large Hadron Collider (LHC), the world’s largest and most powerful particle accelerator, have made a remarkable leap in understanding the fundamental forces of nature. For the first time, they have observed quantum entanglement between top quarks—the heaviest elementary particles—at unprecedented energy levels. This discovery not only pushes the boundaries of particle physics but also opens the door to new possibilities in the quest to understand the universe.

At the heart of this discovery is quantum entanglement, one of the most puzzling and fascinating phenomena in the realm of quantum mechanics. Entanglement occurs when two or more particles become linked in such a way that the state of one particle instantaneously influences the state of another, regardless of the distance between them. This defies our classical understanding of the world, where objects should only interact when they are physically close to one another.

Imagine you have two particles, each spinning in a specific direction. Normally, if one particle changes its state, the other should remain unaffected. But with quantum entanglement, a change in the spin or state of one particle immediately alters the other, even if they are light-years apart. It’s as if the particles are communicating across vast distances without any delay.

Scientists say green hydrogen costs could drop by 5%, boosting viability and sustainability.

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An AI robot made by an Austin startup has logged tons of hours helping hospitals keep up with never-ending demand.