Lifeboat Foundation

To get started planning a career that works on one of the world’s most pressing problems, sign up now at https://80000hours.org/isaacarthur.
The Medusa Starship Drive offers us the chance to sail between the stars, propelled by nuclear bombs.

Visit our Website: http://www.isaacarthur.net.
Join Nebula: https://go.nebula.tv/isaacarthur.
Support us on Patreon: / isaacarthur.
Support us on Subscribestar: https://www.subscribestar.com/isaac-a…
Facebook Group: / 1583992725237264
Reddit: / isaacarthur.
Twitter: / isaac_a_arthur on Twitter and RT our future content.
SFIA Discord Server: / discord.

Continue reading “The Medusa Spaceship Drive” »

Perched in the constellation Orion, 1,300 light-years from Earth, lies GW Orionis, a unique triple-star solar system. Unlike most known systems, GW Orionis features two stars orbiting each other closely, while a third star circles at a much greater distance. Surrounding these stars are three enormous, misaligned rings of planet-forming dust, creating a striking bullseye pattern in the sky.

Recent studies, published in Science and The Astrophysical Journal Letters, suggest that these rings may harbor a young planet—or the makings of one. This celestial body could explain the dramatic misalignment of the system’s inner ring, which appears to wobble like a broken gyroscope. If confirmed, this would be the first known planet orbiting three stars simultaneously.

Nienke van der Marel, astrophysicist and co-author of the May 21 study, noted that the combined gravitational pull of the three stars alone cannot account for the rings’ behavior. Instead, the presence of a planet carving a gap in the disk could be disrupting the system’s balance.

Though he doesn’t remember it, Branden Baptiste had his first sickle cell crisis at age 2. Through elementary school, he was in and out of the hospital with pain episodes, not knowing why. As he got older, he learned he had sickle cell disease. His red blood cells were forming sickle shapes and getting stuck in his blood stream, preventing oxygen from reaching his tissues.

“Sickle cell disease has a broad spectrum of severity, and the severity and frequency of complications can wax and wane,” says Matthew Heeney, MD, Branden’s long-time hematologist at Boston Children’s Hospital.

Continue reading “A sickle cell first: Base editing, a new form of gene therapy, leaves patient feeling ‘more than fine’” »

What’s the best way to precisely manipulate a material’s properties to the desired state? It may be straining the material’s atomic arrangement, according to a team led by researchers at Penn State. The team discovered that “atomic spray painting” of potassium niobate, a material used in advanced electronics, could tune the resulting thin films with exquisite control.

The finding, published in Advanced Materials (“Colossal Strain Tuning of Ferroelectric Transitions in KNbO 3 Thin Films”), could drive environmentally friendly advancements in consumer electronics, medical devices and quantum computing, the researchers said.

The process, called strain tuning, alters a material’s properties by stretching or compressing its atomic unit cell, which is the repeating motif of atoms that builds up its crystal structure. The researchers use molecular beam epitaxy (MBE), a technique that involves depositing a layer of atoms on a substrate to form a thin film. In this case, they produced a thin film of strain-tuned potassium niobate.

Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how protein interactions are governed and how mutations influence cellular functions.

Proteins are the molecular machines of life, performing tasks ranging from driving chemical reactions to orchestrating cell communication. For these tasks, proteins must bind to the right partners with precision, avoiding mispairings that could disrupt cellular processes and lead to disease.

Scientists have long been curious about how changes in the sequence of amino acids —the building blocks of proteins—can alter a protein’s binding capabilities. To investigate this question, researchers in the Diss lab analyzed the effects of all possible mutations in a single protein across its interactions with an entire family of partner proteins. They focused on a protein called JUN, which plays a key role in DNA binding and cellular communication.

A new way of mapping activity and connections between different regions of the brain has revealed fresh insights into how higher order functions like language, thought and attention, are organized.

Traditional models of human brain activity represent interactions in pairs between two different brain regions. This is because modeling methods have not developed sufficiently to describe more complex interactions between multiple regions.

A new approach, developed by researchers at the University of Birmingham is capable of taking signals measured through neuroimaging, and creating accurate models from these to show how different brain regions are contributing to specific functions and behaviors. The results are published in Nature Communications.

An experiment more than 10 years in the making has delivered its first glimpse of the hurricane of particles whirring inside subatomic particles called neutrons, laying the groundwork to solve a mystery deep in the heart of matter.

Data from the Central Neutron Detector at the US Department of Energy’s Thomas Jefferson National Accelerator Facility (TJNAF) is already playing a role in describing the quantum map of the neutron’s engine.

“It’s a quite important result for the study of nucleons,” says Silvia Niccolai, a research director at the French National Centre for Scientific Research.

We got a glimpse at what a new cross between a helicopter and a jet aircraft might look like after Bell released a new image. It’s of a model used in wind tunnel tests of its entry in DARPA’s Speed and Runway Independent Technology (SPRINT) program.

Rotorcraft like helicopters have the advantage of vertical takeoffs and landings in rough country but haven’t much in the way of speed. Jet planes have lots of speed but need runways and even the STOVL variety need a properly flat surface to land on. It was long accepted that these were two very different classes of aircraft without much in the way of overlap.

That is, until DARPA initiated its SPRINT program aimed at making the twain meet in an aircraft that could take off, land, and hover like a rotorcraft and then transition into a jet when in vertical flight.

Using an innovative approach, EMBL scientists uncovered key interactions between molecular machines, potentially opening new avenues for drug development.

Choosing a film for a movie night is always a battle. Now imagine if you could pick one that provided a window into some of the most fundamental biological processes that keep us alive. For the first time ever, researchers have captured a real-time molecular movie to show how two essential cellular processes – transcription and translation – interact with each other in bacteria.

Continue reading “World’s First ‘Molecular Movie’: Witness DNA Becoming Life’s Blueprint in Real-Time” »