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Sep 17, 2021

SARS-like viruses may jump from animals to people hundreds of thousands of times a year

Posted by in categories: biotech/medical, habitats

Only two new coronaviruses have spread globally the past 2 decades: SARS-CoV, which caused an outbreak of severe acute respiratory syndrome (SARS) in 2,003 and SARS-CoV-2, the virus that causes COVID-19. But that may just be the tip of the iceberg of undetected infections with related viruses emerging from bats, a new paper claims. In a preprint published yesterday researchers estimate that an average of 400,000 people are likely infected with SARS-related coronaviruses every year, in spillovers that never grow into detectable outbreaks.

The researchers, including Peter Daszak from the EcoHealth Alliance and Linfa Wang from Duke-NUS Medical School in Singapore, created a detailed map of the habitats of 23 bat species known to harbor SARS-related coronaviruses, the group to which SARS-CoV and SARS-CoV-2 belong, and then overlaid it with data on where humans live to create a map of potential infection hot spots. They found that close to 500 million people live in areas where spillovers can occur, including northern India, Nepal, Myanmar, and most of Southeast Asia. The risk is highest in southern China, Vietnam, Cambodia, and on Java and other islands in Indonesia (see map, below).


Study pinpoints Asian regions that could spark the next coronavirus pandemic.

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Sep 17, 2021

Neurologist Explores Link Between COVID and “Brain Fog,” Memory Loss and Dementia

Posted by in categories: biotech/medical, neuroscience, policy

A new Rutgers study will examine how COVID-19 is affecting individuals in a number of cognitive-related areas, including memory loss, “brain fog,” and dementia.

“Many people who recover from mild or moderate COVID-19 notice slowed thinking or memory loss, and this motivated us to leverage our experience in studying cognitive issues related to Alzheimer’s disease, multiple sclerosis, and HIV to examine this phenomenon,” said Dr. William T. Hu, associate professor and chief of cognitive neurology at Rutgers Robert Wood Johnson Medical School and the Institute for Health, Health Care Policy, and Aging Research.

A leading cognitive neurologist and neuroscientist, Dr. Hu is spearheading the characterization of cognitive impairment following mild-to-moderate COVID-19 at Rutgers.

Sep 17, 2021

High-precision THz time-domain ellipsometry for wide-gap semiconductors

Posted by in category: materials

In semiconductor device applications, there is an increasing demand for semiconductors with very high carrier concentrations. The semiconductor material parameters, namely carrier density and mobility, primarily determine device performance. Hence, it is important to accurately characterize the carrier density and mobility of a semiconductor for the development of its device applications.

The use of THz waves, or with wavelengths of around 300 µm and frequency of about 1 THz, in the nondestructive testing of semiconductors has been continuously expanding. Free carriers in a material absorb THz radiation, which makes it possible to estimate the electrical properties of semiconductors using THz waves.

Researchers at Osaka University, in collaboration with Nippo Precision Co., Ltd., developed a THz time-domain ellipsometry system (Tera Evaluator) that extends the range of carrier concentrations measurable by THz waves up to ~1020 cm-3 and potentially higher by improving the precision of said optical technique. In THz time-domain ellipsometry, linearly polarized THz pulses are incident on a sample and the electric field strength of the reflected THz waves as a function of time is measured. Specifically, the reflected waves polarized in the direction parallel ℗ and perpendicular (s) to the plane of incidence are of interest. The ratio of the p-and s-polarization components yields information on the electric permittivity of the sample, allowing for the evaluation of the carrier density and mobility. As such, unlike THz time-domain spectroscopy, THz time-domain ellipsometry does not require reference measurements through an aperture or standard mirror.

Sep 17, 2021

Towards more energy-efficient 2D semiconductor devices

Posted by in categories: computing, quantum physics

According to researchers from the Singapore University of Technology and Design (SUTD), a recently discovered family of two-dimensional (2D) semiconductors could pave the way for high-performance and energy-efficient electronics. Their findings, published in npj 2D Materials and Applications, may lead to the fabrication of semiconductor devices applicable in mainstream electronics and optoelectronics—and even potentially replace silicon-based device technology altogether.

In the quest of miniaturizing electronic devices, one well-known trend is Moore’s law, which describes how the number of components in the integrated circuits of computers doubles every two years. This trend is possible thanks to the ever-decreasing size of transistors, some of which are so small that millions of them can be crammed onto a chip the size of a fingernail. But as this trend continues, engineers are starting to grapple with the inherent material limitations of silicon-based device technology.

“Due to the quantum tunneling effect, shrinking a silicon-based transistor too small will lead to highly uncontrollable device behaviors,” said SUTD Assistant Professor Ang Yee Sin, who led the study. “People are now looking for new materials beyond the ‘silicon era’, and 2D semiconductors are a promising candidate.”

Sep 17, 2021

What Are Robot Soldiers Doing on the Gaza Border Wall?

Posted by in category: robotics/AI

Is this US ready for this Eric Klien?


Israeli defense technology continues to improve.

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Sep 17, 2021

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Posted by in category: biotech/medical

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of existing vaccines and therapeutic antibodies and underscores the need for additional antibody-based tools that potently neutralize variants by targeting multiple sites of the spike protein. We isolated 216 monoclonal antibodies targeting SARS-CoV-2 from plasmablasts and memory B cells collected from patients with coronavirus disease 2019. The three most potent antibodies targeted distinct regions of the receptor-binding domain (RBD), and all three neutralized the SARS-CoV-2 Alpha and Beta variants. The crystal structure of the most potent antibody, CV503, revealed that it binds to the ridge region of SARS-CoV-2 RBD, competes with the angiotensin converting enzyme 2 receptor, and has limited contact with key variant residues K417, E484 and N501. We designed bispecific antibodies by combining non-overlapping specificities and identified five bispecific antibodies that inhibit SARS-CoV-2 infection at concentrations of less than 1 ng/mL. Through a distinct mode of action, three bispecific antibodies cross-linked adjacent spike proteins using dual N-terminal domain-RBD specificities. One bispecific antibody was greater than 100-fold more potent than a cocktail of its parent monoclonals in vitro and prevented clinical disease in a hamster model at a 2.5 mg/kg dose. Notably, two bispecific antibodies in our panel comparably neutralized the Alpha, Beta, Gamma and Delta variants and wild-type virus. Furthermore, a bispecific antibody that neutralized the Beta variant protected hamsters against SARS-CoV-2 expressing the E484K mutation. Thus, bispecific antibodies represent a promising next-generation countermeasure against SARS-CoV-2 variants of concern.


Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus.

Sep 17, 2021

This drone-deploying blimp could be Amazon’s next aerial fulfillment center

Posted by in categories: drones, robotics/AI

An army of drones descending over a city from a massive corporate airship…damn, amazon just out-cyberpunked cyberpunk itself.


While the origin of this video has something, in part, to do with April Fool’s day, there’s some truth to this concept too. Amazon has, for long, been experimenting with aerial deliveries, sending unmanned drones to fulfill package deliveries. In fact, the blimp idea isn’t completely far-fetched, either. Click the below link to read the entire article.

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Sep 16, 2021

FDA Approves First Human Trial for Potential CRISPR-Led HIV Cure

Posted by in category: biotech/medical

The first-in-human clinical trial for a candidate treatment for individuals living with human immunodeficiency virus type 1 is starting soon after its maker, Excision BioTherapeutics, today received an Investigational New Drug clearance from the U.S. Food and Drug Administration (FDA).

The FDA’s IND approval sets the stage for the very first Phase I/II trial to evaluate EBT-101 as a functional cure for chronic HIV based on the endpoints of safety, tolerability, and efficacy.

EBT-101, an in vivo, CRISPR-based drug that targets HIV proviral DNA, is a unique gene therapy that leverages CRISPR’s viral defense capability against bacteria. It uses an adeno-associated virus (AAV) to deliver a one-time treatment to functionally cure HIV infections. Preclinical studies show that it can excise HIV proviral DNA in multiple cell lines, including both human primary cells and multiple animal models and non-human primates.

Sep 16, 2021

Additively Manufactured Self-Healing Structures with Embedded Healing Agent Reservoirs

Posted by in categories: biotech/medical, computing

The short curing time and consequently quick healing process is advantageous for these self-healing structures with embedded healing agent reservoirs compared to many other previously reported self-healing materials. For instance, self-healing materials with microvascular networks reported by Toohey et al.18 needed to be kept at room temperature for a period of 12 hours in order to become healed. Self-healing materials with interpenetrating microvascular networks reported by Hansen et al.32 had to go under cyclic bending (50 cycles at 100 μ m displacement) to enhance the mixing of the healing agents at the location of the crack, and after that required to be subjected to 48 hours of curing at 30 °C.

Various mechanical tests were conducted to investigate the healing capability of the structures. For each test, three identical samples with an overall dimension of 5 × 10 × 77 mm (H × W × L) were printed using a top-down SLA-based 3D printer. A notch with equal width and depth of 200 µm was incorporated in the middle of the CAD (computer aided design) model of two out of three specimens (Fig. 1a). This notch enhances the repeatability of the experiments and encourages the initiation of a straight crack under flexural (3-point bending) tests32. When a crack forms, propagates, and reaches the reservoir, the resin wicks into the crack planes as a result of capillary forces and closes the crack when it becomes cured under exposure to UV light. These forces are not high enough to drain out and deplete the large amount of healing agent in the reservoirs. The agent’s relatively high viscosity, approximately 850‑1000 cps at 25 °C, further aids in limiting its flow out of the damaged area. After healing, the specimen is tested again, and a new crack is formed under a new critical load and the aforementioned process is repeated. The small amount of leaked healing agent in the self-healing samples becomes cured relatively quickly under the UV radiation with a wavelength of 405 nm. A UV-light source was employed to cure the leaked-healing agent for 3 min. at 50 °C. To compare the effectiveness of the capillary forces for filling the crack, the notch of the second sample was manually filled before the tests. The last unnotched specimen (virgin) remained unfilled and was tested to provide a reference. It is worth noting that for simplicity’s sake, the structures were placed into a UV oven for curing; however, other types of UV sources can initiate and complete the healing process. In the case of a difficult to access part, on-site repair can be easily implemented using a remote UV source. Additionally, unloading the structure is not necessary to the healing process. A damaged structure is able to cure under loading as the healing mechanism is not affected.

The samples underwent tensile tests following the ASTM D638 standard and their force-displacement curves were recorded at a constant crosshead speed of 13 mm min−1. Figure 2 shows the force-displacement curves for each specimen type. There was a difference of 22% between the tensile fracture load of the virgin specimen without a notch and the sample that was manually repaired. By comparing the fracture force of the healed sample before and after healing (182 N for Capillary – Cycle 1 and 199 N for Capillary – Cycle 2), it can be seen that the fracture force increases by around 17 N after the sample was repaired. There is a significant difference between the fracture force of the manually repaired sample and the sample after healing (Capillary – Cycle 2). This indicates that the self-healing process is effective and is reviving the original mechanical performance of the structure.

Sep 16, 2021

The man hacking hot water to save the planet

Posted by in categories: cybercrime/malcode, education, sustainability

No matter the price tag, the industry also has to convince consumers it’s worth their time to upgrade to new technologies.

“It’s difficult to get homeowners to change from the technology that they’re used to, especially in staid devices like water heaters, because they think of it as a utility: open the faucet, water comes out,” Callahan told Freethink. “There’s an education process to get them to understand that there’s a better, cheaper, faster, cooler way to [heat water].”

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