Lifeboat Foundation

The electronics were also improved with a new full-color touchscreen interface and a modular wiring system. An RGB LED lighting system adds nice ambiance and could help users create more exciting time lapse videos of their prints. Prusa is even considering releasing an official, though unsupported, Klipper firmware for those users who have grown to love Klipper in other CoreXY printers.

The most exciting feature by far, however, is the new swappable toolhead system. This is similar to the E3D ToolChanger design and lets the printer switch between different extruders during a print, allowing for multicolor or multi-material prints. An innovative calibration routine ensures that quality doesn’t suffer after a tool change.

Prusa Research hasn’t yet announced an official release date, but you can reserve a pre-order by placing a $200 deposit right now. A semi-assembled Prusa XL with a single toolhead will cost $1,999. A Prusa XL with dual toolheads will cost $2,499 and a Prusa XL with five toolheads will cost $3,499.

According to a new report from Korea, Samsung is considering adding water resistance to its cheaper devices, starting with the Galaxy A33.

Hackers have been increasingly using RTF Template Injection method in widespread phishing attacks.

22-year-old hacker, sixth member of an international hacking group called “The Community,” has been jailed for stealing millions in cryptocurrency.

The lower-end Snapdragon 7c+ Gen 3 offers a more modest 60% jump in multi-core CPU performance, and 30% in single-core workloads. The GPU gets a meaningful 70% boost as well.

Qualcomm says the 8cx Gen 3 is manufactured on the 5nm process node, which suggests that it uses Arm’s Cortex-X1 cores or a modified Kryo 680 design — not the newer Arm Cortex-X2. In that respect, it seems similar to the Snapdragon 888, its previous flagship mobile SoCs. Still, the decision to move away from 7nm should mean better performance per watt. But just how powerful is this new high-end chip?

Continue reading “Qualcomm’s new PC chips are good, but they still can’t match Apple’s M1” »

For the first time, computer scientists and mathematicians have used artificial intelligence to help prove or suggest new mathematical theorems in the complex fields of knot theory and representation theory.

The astonishing results have been published today in the pre-eminent scientific journal, Nature.

Professor Geordie Williamson is Director of the University of Sydney Mathematical Research Institute and one of the world’s foremost mathematicians. As a co-author of the paper, he applied the power of Deep Mind’s AI processes to explore conjectures in his field of speciality, representation theory.

ISM001-055 demonstrated highly promising results in multiple preclinical studies including in vitro biological studies, pharmacokinetic and safety studies. The compound significantly improved myofibroblast activation which contributes to the development of fibrosis. ISM001-055’s novel target is potentially relevant to a broad range of fibrotic indications.

“We are very pleased to see Insilico Medicine’s first antifibrotic drug candidate entering into the clinic,” said Feng Ren 0, PhD, CSO of Insilico Medicine. “We believe this is a significant milestone in the history of AI-powered drug discovery because to our knowledge the drug candidate is the first ever AI-discovered novel molecule based on an AI-discovered novel target. We have leveraged our end-to-end AI-powered drug discovery platform, including the usage of generative biology and generative chemistry, to discover novel biological targets and generate novel molecules with drug-like properties. ISM001-055 is the first such compound to enter the clinic, and we expect more to come in the near future [1].”

Previously, Insilico Medicine demonstrated its ability to generate drug-like hit molecules using AI with the publication of the Generative Tensorial Reinforcement Learning (GENTRL) system for a well-known target in record time [2]. It also demonstrated the target’s proof of concept by applying deep learning techniques for the identification of novel biological targets. This novel antifibrotic program combined these target discovery and generative chemistry capabilities. Notably, Insilico Medicine completed the entire discovery process from target discovery to preclinical candidate nomination within 18 months on a budget of $2.6 million.

Circa 2019

You may have heard about Spyros Panapoulos Automotive (SPA) before. It made the news a few times in 2020 before things went quiet for a while, but now it’s back.

Continue reading “The World’s Largest 3D Metal Printer Is Churning Out Rockets” »

You may have heard about Spyros Panapoulos Automotive (SPA) before. It made the news a few times in 2020 before things went quiet for a while, but now it’s back.

The Spyros Panapoulos Automotive Chaos was scheduled to debut at the 2021 Geneva Motor Show, but that never happened. Considering that this is a small startup that likely had a lot riding on the exposure it would have got had the show gone ahead, it’s no surprise that the company has been dormant.

Now SPA has announced its revival on Facebook with a post that includes several images of the Chaos, all computer-generated. Commenters called SPA out on this, but CGI images often highlight certain features that are impossible to capture on camera. unfortunately, the post doesn’t reveal much other than the fact that only 20 units of the Chaos will be built and that models will be made available on every continent.