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Dec 7, 2022

Chemists Discover Why Synonymous DNA Mutations Are Not Always Silent

Posted by in categories: biotech/medical, genetics

Modeling shows how genetic changes that don’t lead to changes in protein sequence can still alter protein function.

New modeling shows how synonymous mutations — those that change the DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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Dec 7, 2022

“Brain on Fire” — Doctors Successfully Treat a Child Suffering From a Mysterious Disease

Posted by in categories: biotech/medical, neuroscience

The sick child’s prognosis, who had not responded to conventional treatment, was bleak. Nevertheless, a group of doctors from Rutgers University thought there could be hope despite the conventional wisdom against pursuing any further treatment.

What transpired over the following several weeks in the fall of 2020, described in a case study recently published in the European Medical Journal, was notable and representative of a newer approach to effectively treating a strange disease, the doctors stated.

The study focuses on the medical case of a 5-year-old girl who suffered from anti-NMDAR (N-methyl-D-aspartate receptor) encephalopathy, a rare and difficult-to-diagnose malfunction of the brain. Unresponsive to treatments, the child had been transferred to a rehabilitation center and been in a catatonic state for three months when a team of Rutgers physicians were called in to help.

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Dec 7, 2022

Toyota unveils hydrogen-powered pickup and SUV

Posted by in categories: sustainability, transportation

Toyota is testing a hydrogen fuel cell-powered pickup and an SUV that burns the gas in an effort to develop alternatives to battery powered electric vehicles.

Dec 6, 2022

BioAge announces positive topline results for clinical trial evaluating muscle atrophy

Posted by in categories: biotech/medical, life extension

BioAge Labs, a clinical-stage biotech developing therapeutics that target the molecular causes of aging to extend healthy human lifespan, today announced positive Phase 1b clinical data for BGE-105, a highly selective, potent, orally available small-molecule agonist of the apelin receptor APJ.

BGE-105 treatment resulted in statistically significant prevention of muscle atrophy relative to placebo in healthy volunteers aged 65 or older after 10 days of strict bed rest.

Longevity. Technology: Muscle atrophy – loss of muscle mass and strength – is a universal feature of human aging that increases the risk of multiple morbidities, shortens lifespan and diminishes quality of life. Hospitalisation and periods of forced inactivity greatly accelerate this loss in older people.

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Dec 6, 2022

Spermidine is a popular longevity supplement – and with good reason, as it has antiaging properties and can suppress inflammation and oxidation

Posted by in categories: biotech/medical, life extension

Spermidine is a popular longevity supplement – and with good reason, as it has antiaging properties and can suppress inflammation and oxidation. Studies have shown the interestingly-named polyamine can increase lifespan in animal models, and research indicates that its decline with aging is linked to the onset of age-related diseases.

Longevity. Technology: All this background is useful if you are wondering if supplements are right for you and if so, which ones to take. However, having a professional perspective is always useful, and founder of Impact Health Dr Halland Chen MD is a Double Board-Certified doctor who is a Partnered Practitioner of spermidineLIFE. We caught up with Dr Chen to find out what it is like practising at the cutting edge of longevity medicine, and what are some of the most promising interventions he recommends to his patients.

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Dec 6, 2022

AI robot terrifies officials, explains our illusion, with Elon Musk

Posted by in categories: Elon Musk, robotics/AI, transportation

AI robots fly, sing, dance, carry cars and respond to Elon Musk. Incredible new robots join Ameca and Boston Dynamics.

To learn more about AI, please visit https://brilliant.org/digitalengine where you’ll also find loads of fun courses on maths, science and computer science.

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Dec 6, 2022

Elon Musk converts some Twitter offices into bedrooms at San Francisco HQ in light of ‘hardcore’ ultimatum

Posted by in category: Elon Musk

One of Twitter’s office bedrooms has a queen size bed, a bedside table, two armchairs, and an orange carpet, per Forbes.

Dec 6, 2022

Developmental genetics: How germ cells cut the cord from their parents

Posted by in categories: biotech/medical, genetics

For the first cell to develop into an entire organism, genes, RNA molecules and proteins have to work together in a complex way. At first, this process is indirectly controlled by the mother. At a certain point in time, the protein GRIF-1 ensures that the offspring cut themselves off from this influence and start their own course of development. A research team from Martin Luther University Halle-Wittenberg (MLU) details how this process works in the journal Science Advances.

When a new organism starts to develop, the mother calls the shots. During fertilization, the and sperm fuse to form a single new cell. However, the course of , and thus how a new living being forms, is initially determined by the .

“Regardless of the organism, cell division is initially pre-programmed by the mother,” explains geneticist Professor Christian Eckmann from MLU. The mother’s cell provides a developmental starter set that includes the first proteins as well as the RNA molecules that serve as blueprints for further proteins. All this is necessary to jump start cell division and an organism’s development.

Dec 6, 2022

A genome-wide association study for overlap of 12 psychiatric disorders

Posted by in categories: biotech/medical, genetics, neuroscience

A team of researchers from Vrije Universiteit Amsterdam in the Netherlands and the Veterans Administration in the U.S. has conducted a genome-wide association study looking into genetic overlap between 12 common psychiatric disorders. The group describes profiling pleiotropic genetic incidences to 12 common psychiatric disorders in their paper published in the journal Nature Genetics.

Many years ago, psychiatrists and other preferred to think of psychiatric conditions as separate diseases, unrelated to one another. More recently, genetics findings involved in psychiatric disorders have suggested that not only are some of them related, but some have overlap, which suggests that illnesses such as might have multiple forms, giving rise to a spectrum of diseases.

In this new effort, the research team conducted a cross-examination of 12 , looking specifically for genetic overlap. Their work involved conducting a cross-trait meta-analysis to study the impact of single-nucleotide polymorphisms (SNPs), genes in general, cells, pathways and tissue types that might be shared by the 12 disorders ADHD, alcoholism, anorexia, anxiety disorder, autism, bipolarism, depression, OCD, PTSD, schizophrenia and Tourette syndrome.

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Dec 6, 2022

RAADfest 2022 Bill Faloon Age Reversal Research Progress

Posted by in category: futurism

This is Bill Faloon’s keynote presentation at RAADfest 2022 about the rapid progress of age reversal research in 2022.

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