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Mar 25, 2024

First three patients in the trial showed dramatic responses within days

Posted by in categories: biotech/medical, neuroscience

A collaborative project to bring the promise of cell therapy to patients with a deadly form of brain cancer has shown dramatic results among the first patients to receive the novel treatment. In a paper published today in The New England Journal of Medicine, researchers from the Mass General Cancer Center, a member of the Mass General Brigham healthcare system, shared the results for the first three patient cases from a phase 1 clinical trial evaluating a new approach to CAR-T therapy for glioblastoma (GBM). The trial, known as INCIPIENT, is designed to evaluate the safety of CARv3-TEAM-E T cells in patients with recurrent GBM. Just days after a single treatment, patients experienced dramatic reductions in their tumors, with one patient achieving near-complete tumor regression. In time, the researchers observed tumor progression in these patients, but given the strategy’s promising preliminary results, the team will pursue strategies to extend the durability of response.

“This is a story of bench-to-bedside therapy, with a novel cell therapy designed in the laboratories of Massachusetts General Hospital and translated for patient use within five years, to meet an urgent need,” said Bryan Choi, MD, PhD, neurosurgeon and associate director of the Center for Brain Tumor Immunology and Immunotherapy, Cellular Immunotherapy Program, Mass General Cancer Center and Department of Neurosurgery. “The CAR-T platform has revolutionized how we think about treating patients with cancer, but solid tumors like glioblastoma have remained challenging to treat because not all cancer cells are exactly alike and cells within the tumor vary. Our approach combines two forms of therapy, allowing us to treat glioblastoma in a broader, potentially more effective way.”

Mar 25, 2024

Scientists create AI models that can talk to each other and pass on skills with limited human input

Posted by in category: robotics/AI

Scientists modeled human-like communication skills and the transfer of knowledge between AIs — so they can teach each other to perform tasks without a huge amount of training data.

Mar 25, 2024

To Live Past 100, Mangia a Lot Less: Italian Expert’s Ideas on Aging

Posted by in category: life extension

Valter Longo, who wants to live to a healthy 120 or 130, sees the key to longevity in diet — legumes and fish — and faux fasting.

Mar 25, 2024

Apple researchers explore dropping “Siri” phrase & listening with AI instead

Posted by in categories: mobile phones, robotics/AI

Tests aim to see if AI models can determine when you’re speaking to your phone without needing a trigger phrase.

Mar 25, 2024

Atomos Space’s first mission on orbit is a trial by fire

Posted by in category: space travel

The company has faced two main issues related to communications and the spacecraft rotation rate — and it’s largely solved both those problems.

Mar 25, 2024

32°N’s liquid-lens sunglasses transform into reading glasses with a swipe

Posted by in category: computing

So what happens if you combine reading glasses with sunglasses and put a chip in that so discretely that nobody can even tell?

That’s what Deep Optics has done with its latest 32°N-branded Muir sunglasses that I’ve been testing for the last few weeks. A swipe on the frame sends an electrical signal to the two liquid crystal lenses to change the state of millions of tiny pixels so that close objects come into focus.

As such, these 32 Degrees North specs eliminate the need to carry (and lose) both reading glasses and sunglasses — at least, that’s the promise made in exchange for $849 of your hard-earned money.

Mar 25, 2024

Researchers train AI to identify diagnose COVID-19 from ultrasound images

Posted by in categories: biotech/medical, robotics/AI

AI technology developed by Johns Hopkins University to detect COVID-19 in lung ultrasound images, revolutionizing medical diagnostics.

Mar 25, 2024

Researchers reveal highly efficient bit-switch using skyrmions

Posted by in categories: robotics/AI, sustainability

Researchers develop skyrmion-based microelectronic device for sustainable, high-performance AI computing with energy-efficient technology.

Mar 25, 2024

Wendy’s gets Google-parent powered drones to deliver fast-food faster

Posted by in categories: drones, food

DoorDash and Wing (an Alphabet company) have announced their first joint drone delivery service in the United States. Targeted at select customers in Christiansburg, Virginia, eligible DoorDash orders from Wendy’s can now be delivered via Wing drone.

Wendy’s orders will be delivered using a Wing drone, which can travel up to 65 mph. Upon reaching its destination, the drone will lower the order to the doorstep using a tether.

Mar 25, 2024

Paper page — SiMBA: Simplified Mamba-Based Architecture for Vision and Multivariate Time series

Posted by in category: innovation

SiMBA

Simplified Mamba-Based Architecture for Vision and Multivariate Time series.

Transformers have widely adopted attention networks for sequence mixing and MLPs for channel mixing, playing a pivotal role in achieving breakthroughs across domains.

Continue reading “Paper page — SiMBA: Simplified Mamba-Based Architecture for Vision and Multivariate Time series” »

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