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The group of Jürgen Knoblich at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, has developed a new method that allows scientists to cultivate brain organoids with distinct cortical areas and front-to-back patterning.

Together with collaborators at the Human Technopole and the University of Milan-Bicocca, they report a method that gives scientists a deeper look into human-specific brain development and disorders. The study was published in Nature Methods on September 18.

Brain organoids are extensively used to study human brain development. Derived from human pluripotent stem cells, the 3D models allow scientists to study unique properties of the human brain. Researchers use cortical organoids to answer fundamental questions such as how the human brain can grow to its large size or how the human brain’s long-range connections form.

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Top quarks and antiquarks produced in the Large Hadron Collider are entangled, a study shows.

Scientists are using ever more sophisticated AI algorithms trained on vast, unlabeled datasets to develop models that can ‘interpret’ biological data to help guide biomolecule design.

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A summary of an argumentative paper by Litt, Eliasmith, Kroon, Weinstein and Thagard.

Randal Koene discusses Whole Brain Emulation on the H+ Magazine podcast. He touches on the subjects of connectomics, neural mapping, optogenetics, and neural prosthesis.

Muir et al. explore threat discrimination in male and female mice and find that, despite similar behavioral acquisition, there are surprising sex differences in the neural encoding that drives suppression of reward seeking under threat.

Single-cell profiling in the human cortex reveals aging-associated transcriptomic changes across all brain cell types, which overlap with effects with Alzheimer’s disease and show a convergent signature with psychopathology across multiple cell types.