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Mar 27, 2024

Genetic secrets from 4,000-year-old teeth illuminate the impact of changing human diets over the centuries

Posted by in categories: genetics, health

Researchers at Trinity College Dublin have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.

Mar 27, 2024

Construction of dual heterogeneous interface between zigzag-like Mo-MXene nanofibers and small CoNi@NC nanoparticles

Posted by in category: nanotechnology

Two-dimensional transition metal carbides (MXene) possess attractive conductivity and abundant surface functional groups, providing immense potential in the field of electromagnetic wave (EMW) absorption. However, high conductivity and spontaneous aggregation of MXene suffer from limited EMW response. Inspired by dielectric–magnetic synergy effect, the strategy of decorating MXene with magnetic elements is expected to solve this challenge.

Mar 27, 2024

Anti–Interleukin-23 Autoantibodies and Severe Infections

Posted by in category: futurism

This editorial describes the science behind a study of an autoimmune response against cytokines in persons with thymoma and severe infections. Read the full editorial:

Mar 27, 2024

This robot predicts when you’re going to smile — and smiles back

Posted by in category: robotics/AI

An AI-powered robot named Emo watches people’s facial expressions and tries to match them, in an effort to make robots more relatable.

By Alex Wilkins

Mar 27, 2024

New “spiral” contact lenses let you see up close and far away

Posted by in category: biotech/medical

Would you wear this? Researchers just revealed a “spiral diopter” contact lens that has multiple focus points, allowing the user to to see clearly at multiple distances. Here’s what volunteers said when they tried it:


New spiral-shaped multifocal lenses bend light in a way that corrects problems seeing up close and far away, even in poor lighting.

Mar 27, 2024

Making Long-Term Memories Requires Nerve-Cell Damage

Posted by in categories: biotech/medical, neuroscience

March 27, 2024—(BRONX, NY)— Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

“Inflammation of brain neurons is usually considered to be a bad thing, since it can lead to neurological problems such as Alzheimer’s and Parkinson’s disease,” said study leader Jelena Radulovic, M.D., Ph.D., professor in the Dominick P. Purpura Department of Neuroscience, professor of psychiatry and behavioral sciences, and the Sylvia and Robert S. Olnick Chair in Neuroscience at Einstein. “But our findings suggest that inflammation in certain neurons in the brain’s hippocampal region is essential for making long-lasting memories.”

The hippocampus has long been known as the brain’s memory center. Dr. Radulovic and her colleagues found that a stimulus sets off a cycle of DNA damage and repair within certain hippocampal neurons that leads to stable memory assemblies—clusters of brain cells that represent our past experiences. Elizabeth Wood, a Ph.D. student, and Ana Cicvaric, a postdoc in the Radulovic lab, were the study’s first authors at Einstein.

Mar 27, 2024

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Posted by in categories: biotech/medical, life extension

Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis. Ablation of intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged ISCs. This intervention improves epithelial integrity and mucosal immune function. Overall, these results highlight the ability of senolytic CAR T cells to rejuvenate the intestinal niche and demonstrate the potential of targeted cell therapies to promote tissue regeneration in aging organisms.

PubMed Disclaimer

Mar 27, 2024

Parkinson’s warning in skin biopsy

Posted by in categories: biotech/medical, neuroscience

Medical office procedure identifies key biomarker that may lead to more reliable diagnosis of neurodegenerative disorders.

Mar 27, 2024

Into the Unknown: Environmental Testing of the Europa Clipper Spacecraft

Posted by in category: space

“There still is work to be done, but we’re on track for an on-time launch,” said Europa Clipper Project Manager, Jordan Evans. “And the fact that this testing was so successful is a huge positive and helps us rest more easily.”


Like all spacecraft leading up to their launch date, NASA’s Europa Clipper has been undergoing rigorous tests and checkouts to ensure all systems are functioning properly, with NASA engineers recently subjecting the bus-sized orbiter to extreme environmental testing over a 16-day period to ensure the spacecraft can withstand the harsh conditions it will face during its 4-year science mission to the small, ocean world. These harsh conditions not only include the vacuum of space, but also electromagnetic radiation since it will be flying through Jupiter’s massive and powerful magnetic field throughout its mission.

“These were the last big tests to find any flaws,” said Jordan Evans, who is the Europa Clipper Project Manager at the NASA Jet Propulsion Laboratory (JPL). “Our engineers executed a well-designed and challenging set of tests that put the system through its paces. What we found is that the spacecraft can handle the environments that it will see during and after launch. The system performed very well and operates as expected.”

Continue reading “Into the Unknown: Environmental Testing of the Europa Clipper Spacecraft” »

Mar 27, 2024

We’ve glimpsed something that behaves like a particle of gravity

Posted by in categories: particle physics, space

Gravitons, the particles thought to carry gravity, have never been seen in space – but something very similar has been detected in a semiconductor.

By Karmela Padavic-Callaghan

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