Scientists are studying the genes of “superagers” in hopes of identifying targets for therapies and treatments to help people live longer, healthier lives.

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Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with the New York Stem Cell Foundation, sent tiny clumps of stem-cell derived brain cells called “organoids” to the International Space Station (ISS).

Surprisingly, the organoids were still healthy when they returned from orbit a month later, but the cells had matured faster compared to identical organoids grown on Earth—they were closer to becoming adult neurons and were beginning to show signs of specialization. The results, which could shed light on potential neurological effects of space travel, appear in Stem Cells Translational Medicine.

“The fact that these cells survived in space was a big surprise,” says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research. “This lays the groundwork for future experiments in space, in which we can include other parts of the brain that are affected by neurodegenerative disease.”

The protective proteins in our bodies aren’t just great for fending off infection—they could also fight the effects of getting older.

Dr. Ethell’s groundbreaking research serves as the foundation for Leucadia Therapeutics’ work. A PhD in Neuroscience, he has studied Alzheimer’s disease for 20 years. He was a Human Frontiers of Science Long-term Fellow at the Max Planck Institute for Psychiatry in Germany and a Research Associate at the Scripps Research Institute in La Jolla, California. Dr. Ethell ran Alzheimer’s disease research at the La Jolla Institute for Immunology, served on the faculty at the University of California Riverside, and later founded the Molecular Neurobiology Group at the Western University of Health Sciences in Pomona, California, where he also chaired the Department of Neuroscience. He has authored more than 85 papers and presentations.

The Coalition for Radical Life Extension and Longevity Escape Velocity Foundation are bringing together the best in longevity research with the best in anti-aging and age-reversal practices.
The critical research Aubrey de Grey Ph.D. has curated through his renowned Longevity Summit will now be featured at RAADfest, alongside the most advanced and relevant clinical practices for impacting longevity today. RAADfest is the largest and most immersive event in the world focused on super-longevity for a general audience.

Bringing together cutting-edge science, inspiration, entertainment and fun, RAADfest is more than just a conference – it’s a celebration of life. RAADfest provides the information and inspiration to enable people to take charge of their longevity. Produced by the Coalition for Radical Life Extension, whose mission is to align people, resources and policies to our shared vision of curing aging.
https://www.raadfest.com/

Unlocking The Potential Of Blood — Dr. Jackie Kunzler Ph.D. — Senior Vice President, Global R&D, Terumo Blood and Cell Technologies.

Dr. Jackie Kunzler, Ph.D. is Senior Vice President and Global Head of Research and Development (R&D), and member of the Executive Management Committee, of Terumo Blood and Cell Technologies (https://www.terumobct.com/), where she focuses on innovation and development leading the way for unlocking the potential of blood and cell collections in varied sectors, including blood banking, plasma-based therapies and cell and gene therapies.

Dr. Kunzler joined Terumo from Baxter Healthcare where she held successive leadership roles in their business, including as Baxter Healthcare’s Senior Vice President for Quality and Regulatory and Head of Global Life Sciences.

Dr. Kunzler holds a Ph.D. in Cell Biology/Neuroscience from the University of Illinois, Chicago. She earned a Master of Science in Toxicology from the University of Florida, Bachelor’s degrees in Biology and Medical Technology (Laboratory Medicine) from University of Iowa and an MBA in Healthcare Administration from Benedictine University.

#Terumo #JackieKunzler #Blood #SickleCell #Alzheimers #Dementia #Biotherapies #Immunology #TherapeuticApheresis #AutoimmuneDiseases #BloodDisorders #BloodBanking #TransfusionMedicine #RegenerativeMedicine #TherapeuticPlasmaExchange #ConvalescentPlasma #ExtracorporealPhotopheresis #Parabiosis #Longevity #Aging #HospiceCare #STEM #Innovation #Science #Technology #Research #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast

Dr. Ariel Zeleznikow-Johnston hopes to pick up the movement where Jones left off, albeit with the significant twist that his version does not require freezing. A research fellow at Melbourne’s Monash University, Zeleznikow-Johnston wrote the new book, “The Future Loves You: How and Why We Should Abolish Death,” which makes the case that cryopreservation is possible and should be more widely available. Rejecting the popular notion that death endows life with meaning as “palliative philosophy,” Zeleznikow-Johnston’s book instead argues a human’s connectome — a high-resolution map of all their brain connections — could be theoretically recorded perfectly before they die.

Once that happens, that same internal brain activity could be recreated through high-powered computers, while a new brain is grown in a vat via stem cells or some combination of the two. As such, Zeleznikow-Johnston is proposing a spiritual descendant to the cryonics movement (which he dismisses as “unscientific” and “unsubstantiated”), one where the focus is not on preserving tissues but on the “data,” so to speak, of our distinct connectomes.

“We have very strong evidence that the static structure of the neurons is enough to hold onto someone’s memories and personality.”

Futurism, transhumanism, bioethics, ethics, science, philosophy, artificial intelligence, personhood.

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3:45 Does Russian thought have anything to contribute to the world?
15:30 Nikolay Fedorov, an eccentric thinker who influenced Tolstoy and Dostoyevsky.
24:17 Fedorov’s plan: Immortality for everyone.
31:48 ‘Kinship’ as a fundamental property of all matter.
45:13 A mass movement for the spiritual unity of humankind.
01:13:09 Vladimir Solovyov’s The Meaning of Love: Sexuality as a path to a Christian utopia.
01:36:27 Christ as the ultimate role model.

Watch this conversation on MeaningofLife.tv: http://meaningoflife.tv/videos/37671

Nikita Petrov (MeaningofLife.tv) and George Young (University of New England, The Russian Cosmists)

Recorded on December 7, 2016.

Introduction: The lips fulfill various critical physiological roles besides being viewed as a fundamental aesthetic feature contributing to the perception of health and beauty. Therefore, any lip injury, abnormality, or congenital malformation, such as cleft lip, needs special attention in order to restore proper lip function and aesthetics. To achieve this goal, a better understanding of the complex lip anatomy, function, and biology is required, which can only be provided by basic research endeavors. However, the current lack of clinically relevant human lip cells and three-dimensional in vitro lip models, capable of replacing ethically questionable animal experimentations, represents a significant limitation in this area of research.

Methods: To address these limitations, we aimed to pioneer the introduction of immortalized healthy lip-and cleft lip-derived keratinocytes. Primary keratinocytes were isolated from patients’ samples and immortalized by introducing the catalytic domain of telomerase, combined with the targeted knockdown of the cell cycle inhibitor gene, p16^INK4A. We then focused on validating the newly established cell lines by comparing their genetic stability and key phenotypic features with their primary keratinocyte counterparts.

Results: The newly established immortalized keratinocyte cell lines demonstrated genetic stability and preserved the main phenotypic characteristics of primary keratinocytes, such as cellular morphology and differentiation capacity. Three-dimensional lip models, generated using these cell lines, proved to be effective and convenient platforms for screening applications, including wound healing and microbial infection of the lip epithelium.