Combining lab-grown muscle tissue with a series of flexible mechanical joints has led to the development of an artificial hand that can grip and make gestures. The breakthrough shows the way forward for a new kind of robotics with a range of potential applications.

While we’ve seen plenty of soft robots at New Atlas and a truly inspiring range of mechanical prosthetics, we’ve yet to see too many inventions that quite literally combine human tissue with machines. That’s likely because the world of biohybrid science is still in its very early stages. Sure, there was an artificial fish powered by human heart cells and a robot that used a locust’s ear to hear, but in terms of the practical use of the technology, the field has remained somewhat empty.

Now though, researchers at the University of Tokyo and Waseda University in Japan have shown a breakthrough demonstrating the real promise of the technology.

Nanozymes are a class of nanomaterials that exhibit catalytic functions analogous to those of natural enzymes. They demonstrate considerable promise in the biomedical field, particularly in the treatment of bone infections, due to their distinctive physicochemical properties and adjustable catalytic activities. Bone infections (e.g., periprosthetic infections and osteomyelitis) are infections that are challenging to treat clinically. Traditional treatments often encounter issues related to drug resistance and suboptimal anti-infection outcomes. The advent of nanozymes has brought with it a new avenue of hope for the treatment of bone infections.

UC Davis Health is pleased to announce that Neurosurgeon David Brandman and his team at UC Davis Neuroprosthetics Lab were selected for a 2025 Top Ten Clinical Research Achievement Award. The Clinical Research Forum presents this award to honor 10 outstanding clinical research studies published in peer-reviewed journals in the previous year. This year’s Top 10 Awards ceremony will be held on April 14 in Washington, D.C.

Brandman and his team are recognized for their groundbreaking work in developing a new brain-computer interface (BCI) that translates brain signals into speech with up to 97% accuracy — the most accurate system of its kind. Their work was published in the New England Journal of Medicine.

“Our team is very honored that our study was selected among the nation’s best published clinical research studies. Our work demonstrates the most accurate speech neuroprosthesis (device) ever reported,” said Brandman, co-director of the Neuroprosthetics Lab. He is an assistant professor in the UC Davis Department of Neurological Surgery.

Advances in brain-computer interfaces enable paralysed users to feel objects in a realistic way via a robotic limb.

A class of synthetic soft materials called liquid crystal elastomers (LCEs) can change shape in response to heat, similar to how muscles contract and relax in response to signals from the nervous system. 3D printing these materials opens new avenues to applications, ranging from soft robots and prosthetics to compression textiles.

Controlling the material’s properties requires squeezing this elastomer-forming ink through the nozzle of a 3D printer, which induces changes to the ink’s internal structure and aligns rigid building blocks known as mesogens at the molecular scale. However, achieving specific, targeted alignment, and resulting properties, in these shape-morphing materials has required extensive trial and error to fully optimize printing conditions. Until now.

In a new study, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), Princeton University, Lawrence Livermore National Laboratory, and Brookhaven National Laboratory worked together to write a playbook for printing liquid crystal elastomers with predictable, controllable alignment, and hence properties, every time.

Biopunk androids replicants.

What happens when humans begin combining biology with technology, harnessing the power to recode life itself.

What does the future of biotechnology and genetic engineering look like? How will humans program biology to create organ farm technology and bio-robots. And what happens when companies begin investing in advanced bio-printing, artificial wombs, and cybernetic prosthetic limbs.

Researchers are paving the way for the design of bionic limbs that feel natural to users. They demonstrate the connection between hand movement patterns and motoneuron control patterns. The study, published in Science Robotics, also reports the application of these findings to a soft prosthetic hand, which was successfully tested by individuals with physical impairments.

The research study sees the collaboration of two research teams, one at Istituto Italiano di Tecnologia (Italian Institute of Technology) in Genova, Italy, led by Antonio Bicchi, and Imperial College London, UK led by Dario Farina. It is the outcome of the project “Natural BionicS” whose goal is to move beyond the model of current prosthetic limbs, which are often abandoned by patients because they do not respond in a “natural” way to their movement and control needs.

For the central nervous system to recognize the bionic limb as “natural,” it is essential for the prosthesis to interact with the environment in the same way a real limb would. For this reason, researchers believe that the prostheses should be designed based on the theory of sensorimotor synergies and soft robotics technologies, first proposed by Antonio Bicchi’s group at IIT, such as the Soft-Hand robotic hand.

Recent technological advances have opened new possibilities for the development of assistive and medical tools, including prosthetic limbs. While these limbs used to be hard objects with the same shape as limbs, prosthetics are now softer and look more realistic, with some also integrating robotic components that considerably broaden their functions.

Despite these developments, most commercially available robotic limbs cannot be easily and intuitively controlled by users. This significantly limits their effectiveness and the extent to which they can improve people’s quality of life.

Researchers at the Italian Institute of Technology (IIT) and Imperial College London recently developed a new soft prosthetic hand that could be easier for users to control. This system, presented in a Science Robotics paper, leverages a new control approach that integrates the coordination patterns of multiple fingers (i.e., postural synergies) with the decoding of the activity of motoneurons in people’s spinal column.

Wandering salamanders are known for gliding high through the canopies of coastal redwood forests, but how the small amphibians stick their landing and take-off with ease remains something of a mystery.

A new study in the Journal of Morphology reveals the answer may have a lot to do with a surprising mechanism: blood-powered toes. The Washington State University-led research team discovered that wandering salamanders (Aneides vagrans) can rapidly fill, trap and drain the blood in their toe tips to optimize attachment, detachment and general locomotion through their arboreal environment.

The research not only uncovers a previously unknown physiological mechanism in salamanders but also has implications for bioinspired designed. Insights into salamander toe mechanics could ultimately inform the development of adhesives, prosthetics, and even robotic appendages.

Two new papers document progress in neuroprosthetic technology that lets people feel the shape and movement of objects moving over the “skin” of a bionic hand.