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Category: biotech/medical – Page 2,146

Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season. — PubMed — NCBI

“Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference…” “…Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections.”

Vaccine. 2020 Jan 10;38:350–354. doi: 10.1016/j.vaccine.2019.10.005. Epub 2019 Oct 10.

PURPOSE: Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. Test-negative study designs are often utilized to calculate influenza vaccine effectiveness. The virus interference phenomenon goes against the basic assumption of the test-negative vaccine effectiveness study that vaccination does not change the risk of infection with other respiratory illness, thus potentially biasing vaccine effectiveness results in the positive direction. This study aimed to investigate virus interference by comparing respiratory virus status among Department of Defense personnel based on their influenza vaccination status. Furthermore, individual respiratory viruses and their association with influenza vaccination were examined.

RESULTS: We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing vaccinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p = 0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N = 6120), non-influenza positive controls (N = 2880), and pan-negative controls (N = 3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46−0.51).

Doctors use CRISPR gene editing inside a person’s body for first time

Scientists say they have used the gene editing tool CRISPR inside someone’s body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases.

A patient recently had it done at the Casey Eye Institute at Oregon Health & Science University in Portland for an inherited form of blindness, the companies that make the treatment announced Wednesday. They would not give details on the patient or when the surgery occurred.

It may take up to a month to see if it worked to restore vision. If the first few attempts seem safe, doctors plan to test it on 18 children and adults.

Our Genetic Future Is Coming… Faster Than We Think

If there was a public vote about human gene enhancement, would you vote YES or NO?

Our species is on the cusp of a revolution that will change every aspect of our lives but we’re hardly talking about it.

After three and a half billion years of evolution, two hundred and fifty thousand years of them as the ass-kicking bipedal hominins we call homo sapiens, we are on the verge of taking control of our evolutionary process unlike never before. This revolution will take hundreds of years to play out but it has already begun.

Sure, we influenced natural selection when we invented farming and modern medicine, but take a human baby from eleven thousand years ago and place him in a modern family and he’ll grow up just like any other kid. Then take a kid from a thousand years from now and place him in the same family. My belief is that the future child brought back to the present will not fit in nearly as well. He will be stronger and smarter with enhanced sensory and other capabilities. And we will have engineered him. We will have engineered us all.

Chinese scientists identify two strains of the coronavirus, indicating it’s already mutated at least once

Researchers in China have found that two different types of the new coronavirus could be causing infections worldwide.

In a preliminary study published Tuesday, scientists at Peking University’s School of Life Sciences and the Institut Pasteur of Shanghai found that a more aggressive type of the new coronavirus had accounted for roughly 70% of analyzed strains, while 30% had been linked to a less aggressive type.

WHO says coronavirus death rate is 3.4% globally, higher than previously thought

World health officials said Tuesday the mortality rate for COVID-19 is 3.4% globally, higher than previous estimates of about 2%.

“Globally, about 3.4% of reported COVID-19 cases have died,” WHO Director-General Tedros Adhanom Ghebreyesus said during a press briefing at the agency’s headquarters in Geneva. In comparison, seasonal flu generally kills far fewer than 1% of those infected, he said.

CRISPR Scientists Hack Patient’s Genes in Bid to Cure Blindness

For the first time, doctors have attempted to cure blindness by gene-hacking a patient with CRISPR technology.

A team from Oregon Health & Science Institute injected three droplets of fluid that delivered the CRISPR DNA fragments directly into a patient’s eyeball, The Associated Press reports, in hopes that it will reverse a rare genetic condition called Leber congenital amaurosis, which causes blindness early in childhood.

“We literally have the potential to take people who are essentially blind and make them see,” Charles Albright, chief scientific officer of Editas Medicine, told the AP. Editas is one of the biotech companies that actually developed the treatment. “We think it could open up a whole new set of medicines to go in and change your DNA.”

CDC: Get Ready to Stay At Home For a While

During a Tuesday briefing, the CDC’s director of the National Center for Immunization and Respiratory Diseases Nancy Messonnier warned that self-imposed quarantines could last weeks.

“You may need to take a break from your normal daily routine for two weeks,” she said, as quoted by The Washington Post.

“Staying home when you are sick is really important,” she added. “Don’t let the illness spread beyond you. Stay away as much as you can from other people.”

Genome Assembly — The Holy Grail of Genome Analysis

The 2019 novel coronavirus or coronavirus disease (COVID-19) outbreak has threatened the entire world at present. Scientists are working day and night to understand the origin of COVID-19. You may have heard the news recently that the complete genome of COVID-19 has been published. How did scientists figure out the complete genome of COVID-19? In this article, I will explain how we can do this.

A genome is considered as all the genetic material, including all the genes of an organism. The genome contains all the information of an organism that is required to build and maintain it.

How can we read the information present in the genome? This is where sequencing comes into action. Assuming you have read my previous article on DNA analysis, you know that sequencing is used to determine the sequence of individual genes, full chromosomes or entire genomes of an organism.

Global Organization and Proposed Megataxonomy of the Virus World

Viruses and mobile genetic elements are molecular parasites or symbionts that coevolve with nearly all forms of cellular life. The route of virus replication and protein expression is determined by the viral genome type. Comparison of these routes led to the classification of viruses into seven “Baltimore classes” (BCs) that define the major features of virus reproduction. However, recent phylogenomic studies identified multiple evolutionary connections among viruses within each of the BCs as well as between different classes. Due to the modular organization of virus genomes, these relationships defy simple representation as lines of descent but rather form complex networks. Phylogenetic analyses of virus hallmark genes combined with analyses of gene-sharing networks show that replication modules of five BCs (three classes of RNA viruses and two classes of reverse-transcribing viruses) evolved from a common ancestor that encoded an RNA-directed RNA polymerase or a reverse transcriptase. Bona fide viruses evolved from this ancestor on multiple, independent occasions via the recruitment of distinct cellular proteins as capsid subunits and other structural components of virions. The single-stranded DNA (ssDNA) viruses are a polyphyletic class, with different groups evolving by recombination between rolling-circle-replicating plasmids, which contributed the replication protein, and positive-sense RNA viruses, which contributed the capsid protein. The double-stranded DNA (dsDNA) viruses are distributed among several large monophyletic groups and arose via the combination of distinct structural modules with equally diverse replication modules. Phylogenomic analyses reveal the finer structure of evolutionary connections among RNA viruses and reverse-transcribing viruses, ssDNA viruses, and large subsets of dsDNA viruses. Taken together, these analyses allow us to outline the global organization of the virus world. Here, we describe the key aspects of this organization and propose a comprehensive hierarchical taxonomy of viruses.