Innovation At The Frontiers Of Aesthetic And Regenerative Medicine — Prof. Dr. Alan Widgerow — Division Chief, Center for Tissue Engineering, UCIrvine — Chief Scientific Officer, Galderma.

Prof. Dr. Alan Widgerow, MBBCh, FCS, MMed, FACS, is Division Chief, Research, Center for Tissue Engineering (https://sites.uci.edu/ctelab/team/) and Adjunct Professor Plastic Surgery, Dept of Plastic Surgery, University of California, Irvine (https://faculty.uci.edu/profile/?facu…) and Chief Scientific Officer and Head of Skin Science Center of Innovation at Galderma (https://www.galderma.com/).

Prof. Widgerow is a plastic surgeon who ran a solo private practice in South Africa for over 20 years.

Prof. Widgerow completed his undergraduate and post-graduate studies at the University of the Witwatersrand, South Africa. He has held various positions in numerous academic and professional associations including that of President of the Association of Plastic and Reconstructive surgery of Southern Africa (APRSSA). He is author of over 190 plastic surgical related publications and 2 books. He was also the founder and medical director of 13 wound clinics in South Africa.

Prof. Widgerow relocated to Irvine California in Dec 2009 to pursue his interests in medical device innovations, cosmeceuticals and wound care, but he still plays an active role in academic medicine world-wide. In 2012 he was appointed to the Faculty of the University of California Irvine Plastic Surgery Dept as Full Adjunct Professor and Director of the Center for Tissue Engineering and in 2021 was appointed as its Division Chief of Research. He is involved in multiple projects related to adipose derived stem cell and adipose decellularized matrix, wound healing and transplantation. In 2018 he was awarded the Distinguished Faculty Mentor of the year Award by the Institute for Clinical and Translational Science, UCI.

Prof. Widgerow has developed and licensed multiple products in the US and South African markets. In 2015 he joined ALASTIN Skincare, Inc. an early start up professional skin care company as their Chief Medical Officer. Over the past 6 years he has spearheaded the scientific innovations team introducing multiple new products based on novel wound healing pathways. The resulting products have been validated with gene expression, in vitro and ex-vivo testing, biopsies, and multiple clinical trials resulting in a range of products that have surpassed previous scientific validations in this space. He continues to pursue patented novel concepts, peptide technologies and vigorous testing thus contributing to Alastin Skincare’s position as the fastest growing professional skin care company in the US for the past 4 years.

In 2021, Alastin Skincare was acquired by Galderma, the largest privately owned dermatology company in the world, and in June 2022, Prof. Widgerow was appointed Chief Scientific Officer of Galderma, Head of the Skin Science Center for Innovation and Head of Alastin innovations. He is involved in aesthetic, prescription and consumer product science research and development.

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Inventing a new, faster way to produce sustainable, self-dyed leather alternatives is a major achievement for synthetic biology and sustainable fashion. Professor Tom Ellis

Synthetic chemical dyeing is one of the most environmentally toxic processes in fashion, and black dyes – especially those used in colouring leather – are particularly harmful. The researchers at Imperial set out to use biology to solve this.

What can earthquake rupture zones teach us about earthquakes and how to predict them? This is what a five-year, $2.3 million grant awarded by the National Science Foundation’s (NSF) Frontier Research in Earth Sciences grant hopes to address as an international team of researchers have been tasked with analyzing samples obtained from the earthquake rupture zone at the Turkey-Syria border responsible for the devastating back-to-back earthquakes on February 6, 2023, that killed more than 50,000 people and registered 7.8-magnitude and 7.6-magnitude, respectively. This study holds the potential to help researchers better understand the geologic processes responsible for large-scale earthquakes and the steps we can take to mitigate damage and loss of life.

“This NSF-funded project will help us overcome limitations of previous, generalized characterizations of earthquake critical zones with more in-depth geologic data, seismic imaging studies, deformation experiments and modeling,” said Dr. Alexis Ault, who is an Associate Professor in the Department of Geosciences at Utah State University (USU), and the lead principal investigator on the project. “Combining expertise from varied engineering and geoscience disciplines, we aim to emerge with a more complete and accurate picture of earthquake critical zones in these settings.”

For the study, the researchers collected geologic samples from the Çardak-Yesilyurt Fault system that was responsible for the devastating 2023 quakes to better understand how pressure builds within the earthquake critical zone, or the region of the Earth’s crust that’s just beneath the surface. Additionally, they will compare these findings to samples obtained from the southern San Andreas fault in California from another grant to help build their data cache, as well. This research builds off a 2023 NSF-funded research trip to the region approximately six months after the devastating quakes occurred.

In the search for less energy-hungry artificial intelligence, some scientists are exploring living computers.

By Jordan Kinard

Artificial intelligence systems, even those as sophisticated as ChatGPT, depend on the same silicon-based hardware that has been the bedrock of computing since the 1950s. But what if computers could be molded from living biological matter? Some researchers in academia and the commercial sector, wary of AI’s ballooning demands for data storage and energy, are focusing on a growing field known as biocomputing. This approach uses synthetic biology, such as miniature clusters of lab-grown cells called organoids, to create computer architecture. Biocomputing pioneers include Swiss company FinalSpark, which earlier this year debuted its “Neuroplatform”—a computer platform powered by human-brain organoids—that scientists can rent over the Internet for $500 a month.

He Jiankui, who went to prison for three years for making the world’s first gene-edited babies, talked to MIT Technology Review about his new research plans.

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.

In a collaboration with EPFL Lausanne, ETH Zurich and the University of Southern California researchers at the Paul Scherrer Institute PSI have used X-rays to look inside a microchip with higher precision than ever before. The image resolution of 4 nanometers marks a new world record. The high-resolution three-dimensional images of the type they produced will enable advances in both information technology and the life sciences.

The researchers are reporting their findings in the current issue of the journal Nature (“High-performance 4 nm resolution X-ray tomography using burst ptychography”).

View inside a state-of-the-art computer chip. Their newly developed ptychographic technique allowed the researchers to map the three-dimensional structure of this engineering marvel. The picture shows the different layers that make up the microchip. The coarser structures can be seen at the top. The microchip becomes increasingly complex as you move down through the layers – making the connections there visible requires a resolution of just a few nanometers. (Image: Tomas Aidukas, Paul Scherrer Institute)

Equitable and accessible education in life sciences, bioengineering, and synthetic biology is crucial for training the next generation of scientists. Here the authors present the CRISPRkit, a cost-effective educational tool that enables high school students to perform CRISPR experiments affordably and safely without prior experience, using smartphone-based quantification and an automated algorithm for data analysis.

At the mere flick of a magnetic field, mice engineered with nanoparticle-activated ‘switches’ inside their brains were driven to feed, socialize, and act like clucky new mothers in an experiment designed to test an innovative research tool.

While ’mind control’ animal experiments are far from new, they have generally relied on cumbersome electrodes tethering the subject to an external system, which not only requires invasive surgery but also sets limits on how freely the test subject can move about.

In what is claimed to be a breakthrough in neurology, researchers from the Institute for Basic Science (IBS) in Korea have developed a method for targeting pathways in the brain using a combination of genetics, nanoparticles, and magnetic fields.

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than the industry standard, CRISPR, which has revolutionized genetic engineering in medicine, agriculture and biotechnology.

SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors.

The new gene-editing tool is being developed by a team led by Dr. Sandro Ataide in the School of Life and Environmental Sciences. Their findings have been published in Nature Communications.