In 2017, Jacob Haendel was living a normal life as a head chef in…

A paralysed man who had an extreme form of locked-in syndrome and heard a nurse say he was “brain dead” has become the first ever to recover after hearing medical professionals debating whether or not to switch off his life support.

In 2017, Jacob Haendel was living a normal life as a head chef in Boston, Massachusetts but in the space of a few weeks, his life was turned upside down after he was diagnosed with acute toxic progressive leukoencephalopathy, which progressed into locked-in syndrome and forced his body would slowly shut down. An extreme form of locked-in syndrome is a condition where a patient is aware but cannot move or communicate verbally due to complete paralysis and can be caused by brain trauma, infection or exposure to toxins.

It is not known exactly how Jacob developed the condition, though he says his life as a chef consuming certain chemicals “wilfully and otherwise” may have been a factor. He ended up paralysed, unable to talk or blink within a few months and, could hear hospital staff deliberating over switching off machines.

DGIST Professor Youngu Lee and Jeonbuk National University Professor Jaehyuk Lim successfully developed an ultra-sensitive, transparent, and flexible electronic skin mimicking the neural network in the human brain. — Applicable across different areas, including healthcare wearable devices and transparent display touch panels.

Whether we’re staring at our phones, the page of a book, or the person across the table, the objects of our focus never stand in isolation; there are always other objects or people in our field of vision. How that visual “clutter” affects visual processing in the brain, however, is not well understood.

In a new study published Oct. 22 in the journal Neuron, Yale researchers show that this clutter alters how information flows in the brain, as does the precise location of that clutter within the wider field of vision. The findings help clarify the neural basis of perception and offer a deeper understanding of the visual cortex in the brain.

The incidence of breast cancer in women has increased significantly over the past few decades, but advancements in targeted therapies have led to a decrease in death…

Breast cancer cells send microRNA-filled vesicles to the brain, creating a nutrient-rich environment that facilitates metastasis.

R.I.P. Phil Philip George Zimbardo. March 23, 1933 – October 14, 2024.

“Success is not about reaching a destination; it’s about the journey and the person you become along the way.”

Philip G. Zimbardo, one of the world’s most renowned psychologists, died Oct. 14 in his home in San Francisco. He was 91.

Broadly, Zimbardo’s research explored how environments influence behavior. He is most known for his controversial 1971 study, the Stanford Prison Experiment, with W. Curtis Banks, Craig Haney, and David Jaffe. The study, intended to examine the psychological experiences of imprisonment, revealed the shocking extent to which circumstances can alter individual behavior. To this day, it is used as a case study in psychology classes to highlight both the psychology of evil as well as the ethics of doing psychological research with human subjects.

Yet Zimbardo’s research went far beyond the prison experiment. In a career that spanned over five decades, Zimbardo examined topics including persuasion, attitude change, cognitive dissonance, hypnosis, cults, alienation, shyness, time perspective, altruism, and compassion.

Australian, American and British researchers conducted a prospective analysis of light levels in almost 89 thousand people and concluded that more light exposure at night and less during the day are associated with an increased risk of death from all causes.

Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts mortality risk has not been established. We therefore investigated whether personal day and night light, and light patterns that disrupt circadian rhythms, predicted mortality risk. UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore light sensors for 1 wk. Day and night light exposures were defined by factor analysis of 24-h light profiles. A computational model of the human circadian pacemaker was applied to model circadian amplitude and phase from light data. Cause-specific mortality was recorded in 3,750 participants across a mean (±SD) follow-up period of 8.0 ± 1.0 y.

A neurological study from the Netherlands reveals that viewing art in person triggers emotions 10 times stronger than seeing the same works in reproduction.

Five artworks induced stronger positive responses in 20 participants in the Netherlands than museum shop posters of the same works.

Researchers from the Sapienza University of Rome found that caffeine has a positive effect on endothelial cells, a group of cells responsible for vascular regeneration.

We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.

Methods.

We enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food frequency questionnaire. EPCs percentage was assessed by flow cytometry analysis and, subsequently, EPCs pooled from six HD were co-cultured with caffeine with and without SLE sera. After 7 days, we evaluated cells’ morphology and ability to form colonies, the percentage of apoptotic cells by flow cytometry analysis and the levels of autophagy and apoptotic markers by western blot. Finally, we performed a western blot analysis to assess the A2AR/SIRT3/AMPK pathway.

Mental health issues are one of the most common causes of disability, affecting more than a billion people worldwide. Addressing mental health difficulties can present extraordinarily tough problems: what can providers do to help people in the most precarious situations? How do changes in the physical brain affect our thoughts and experiences? And at the end of the day, how can everyone get the care they need?

Answering those questions was the shared goal of the researchers who attended the Mental Health, Brain, and Behavioral Science Research Day in September. While the problems they faced were serious, the new solutions they started to build could ultimately help improve mental health care at individual and societal levels.

“We’re building something that there’s no blueprint for,” said Mark Rapaport, MD, CEO of Huntsman Mental Health Institute at the University of Utah. “We’re developing new and durable ways of addressing some of the most difficult issues we face in society.”

Summery:

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Mousavi, S., Seyedmirzaei, H., Shahrokhi Nejad, S. et al. Sci Rep 14, 21,936 (2024). https://doi.org/10.1038/s41598-024-73277-z.