Researchers probe pressures within the proton using Deeply Virtual Compton Scattering to help us understand the building blocks of matter.

By tapping into a decades-old mathematical principle, researchers are hoping that Kolmogorov-Arnold networks will facilitate scientific discovery.

Surprisingly, your past, present, and future could be happening right now, all at the same time.

The block universe theory suggests that time doesn’t flow and all moments—past, present, and future—exist simultaneously in a four-dimensional space. This challenges our conventional experience of time as a linear progression. According to Dr. Kristie Miller, traveling to the past or future might be possible, but changing events isn’t; you’d only fulfill what’s already set. Critics argue that the future can’t be predetermined, with models like the evolving block universe proposing a growing spacetime block. While the debate continues, this theory reshapes our understanding of time and existence. Don’t forget to share your thoughts and join the discussion below!

We seem to experience time as moving in a single direction. After all, we can’t just leap forward to the future or revisit our past whenever we wish. Every minute of every day seems to push us forward, dragging us through life towards an inevitable end. At least, that’s the traditional perception of time. But what if your present, past, and future all exist simultaneously? From this perspective, time wouldn’t flow at all.

It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth — that is, radically reverse our biological aging process to a younger time point without losing cellular identity.

In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials.

Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine.

In this podcast — which is actually two-in-one because I continued the conversation with him on a second date — you’ll hear about the remarkable work they’re undertaking at his lab. For example: They’ve created a biological clock that encompasses the whole genome consisting of millions and millions of CpG sites. They are able to clearly demonstrate the reversal of bioage using their methodology — a cocktail of Yamanaka factors plus, with clear time limits — which changes the epigenome first, and in so doing influences all of the hallmarks of aging. Teaser: they’ve identified one intervention routinely used in clinical practice that influences their bio age clock in the same way that their cocktail does. What is it? I was riveted with this conversation, as I am sure you’ll be. Leave a review if you like it, and — Yes — let me know what you think. I know this will prompt deep questions for you, as it did for me. ~DrKF

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

During aging, the human methylome undergoes both differential and variable shifts, accompanied by increased entropy. The distinction between variably methylated positions (VMPs) and differentially methylated positions (DMPs), their contribution to epigenetic age, and the role of cell type heterogeneity remain unclear.

We conduct a comprehensive analysis of  32,000 human blood methylomes from 56 datasets (age range = 6–101 years). We find a significant proportion of the blood methylome that is differentially methylated with age (48% DMPs; FDR  0.005) and variably methylated with age (37% VMPs; FDR  0.005), with considerable overlap between the two groups (59% of DMPs are VMPs). Bivalent and Polycomb regions become increasingly methylated and divergent between individuals, while quiescent regions lose methylation more uniformly. Both chronological and biological clocks, but not pace-of-aging clocks, show a strong enrichment for CpGs undergoing both mean and variance changes during aging. The accumulation of DMPs shifting towards a methylation fraction of 50% drives the increase in entropy, smoothening the epigenetic landscape. However, approximately a quarter of DMPs exhibit anti-entropic effects, opposing this direction of change.

Your thymus isn’t talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential \.

Dissecting the molecular mechanism controlling the epigenetic profile of pluripotent stem cells.„, European Commission.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pr…

A new superhighway network has been identified by researchers, which enables significantly faster travel through the Solar System than was previously feasible. This network can facilitate the transportation of comets and asteroids from Jupiter to Neptune in under a decade and up to 100 astronomical units within a century.

The technology could facilitate swift transportation of spacecraft to the remote regions of our solar system while also aiding in the detection and understanding of nearby objects that pose a threat of colliding with our planet.

In a paper published on November 25, 2020, in the journal Science Advances, researchers have identified a series of interconnected arches forming space manifolds that extend from the asteroid belt to Uranus and beyond, which create a new “celestial autobahn.” These structures operate on a much shorter time scale of several decades, as opposed to the hundreds of thousands or millions of years characteristic of Solar System dynamics.

Technology.

Queen’s researcher Ryan Grant wants to turn Canada into a global supercomputing leader.