According to the National Institute of Environmental Health Services, nearly 50 million Americans are currently living with an autoimmune condition. It’s the third-largest category of diseases affecting the nation, according to the agency. Doctors and scientists have been using a number of promising CRISPR treatments to address some of these conditions; now, the results of a new study in China could offer a way to make these treatments even more widely available.

As Nature‘s Smriti Mallapaty explains, the study focused on three people whose treatments were created using donor cells as opposed to cells taken from the patients themselves. This is significant because the prospect of using donor cells allows for CRISPR treatments to be developed in larger quantities — something that could make a big difference in a lot of people’s lives around the world.

Mallapaty describes the three patients in the study as having “severe autoimmune conditions.” One of them, a man in his fifties with systemic sclerosis, said that he started feeling better within a few days, and was able to resume working two weeks after the treatment. This particular study isn’t the only one of its kind — Nature‘s reporting mentions that another trial was subsequently conducted with more patients, while another doctor is leading a similar study using donor cells to treat lupus.

Exclusive: Global trial finds treatment with amivantamab and lazertinib halts progression for average of 23.7 months.

The foundation of this simulation, as described by the team, is a well-known cosmological model that describes the universe as expanding uniformly over time. The researchers modeled how a quantum field, initially in a vacuum state (meaning no particles are present), responds to this expansion. As spacetime stretches, the field’s oscillations mix in a process that can create particles where none previously existed. This phenomenon is captured by a transformation that relates the field’s behavior before and after the universe expands, showing how vibrations at different momenta become entangled, leading to particle creation.

To understand how many particles are generated, the researchers used a mathematical tool called the Bogoliubov transformation. This approach describes how the field’s vacuum state evolves into a state where particles can be detected. As the expansion rate increases, more particles are produced, aligning with predictions from quantum field theory. By running this simulation on IBM quantum computers, the team was able to estimate the number of particles created and observe how the quantum field behaves during the universe’s expansion, offering a new way to explore complex cosmological phenomena.

According to the team, the most notable result of the study was the ability to estimate the number of particles created as a function of the expansion rate of the universe. By running their quantum circuit on both simulators and IBM’s 127-qubit Eagle quantum processor, the researchers demonstrated that they could successfully simulate particle creation in a cosmological context. While the results were noisy—particularly for low expansion rates—the error mitigation techniques used helped bring the outcomes closer to theoretical predictions.

In 2018, a discovery in materials science sent shock waves throughout the community. A team showed that stacking two layers of graphene—a honeycomb-like layer of carbon extracted from graphite—at a precise “magic angle” turned it into a superconductor, says Ritesh Agarwal of the University of Pennsylvania.

Quantum mechanics: it’s the realm of science where nothing is normal, and everything seems to undermine the fundaments of our common understanding of reality. Nonetheless, we simple humans tick on.

But quantum physicists, who pride themselves on staring into the abyss and gleaning its spooky secrets, have just discovered another baffling phenomenon to make your mind melt: “negative time.”

As detailed in a yet-to-be-peer-reviewed study covered by Scientific American, a team of researchers say they’ve observed photons exhibiting this bizarre temporal behavior as the result of what’s known as atomic excitation.

But these exciting applications have been limited in part by the tedious process of tunneling individual sub-nanometer pores one by one.

“If we are to ever scale up 2D material membranes to be relevant for applications outside the laboratory, the ‘one pore at a time’ method just isn’t feasible,” said recent UChicago Pritzker School of Molecular Engineering (PME) Ph.D. graduate Eli Hoenig. “But, even within the confines of laboratory experiment, a nanoporous membrane provides significantly larger signals than a single pore, increasing the sensitivity.”

Hoenig is first author of a paper recently published in Nature Communications that found a novel path around this longstanding problem. Under PME Asst. Prof. Chong Liu, the team created a new method of pore generation that builds materials with intentional weak spots, then applies a remote electric field to generate multiple nanoscale pores all at once.

Summary: Neural stem cells, which create new neurons in the brain, become less active with age due to elevated glucose levels. Researchers found that by knocking out the glucose transporter gene GLUT4 in older mice, they could significantly increase the production of new neurons.

This discovery opens up potential pathways for both genetic and behavioral interventions to stimulate brain repair, including the possibility of a low-carbohydrate diet. The findings could help treat neurodegenerative diseases and aid in brain recovery after injury.

Neuromodulation through the eyes

Neuroplasticity, also known as neural plasticity or brain plasticity, is a process that involves adaptive structural and functional changes to the brain.

Founded and directed by Deborah Zelinsky, O.D., F.N.O.R.A., F.C.O.V.D.

Just as with eye-hand coordination, integration of vision and sound – eye-ear connection – must be developed. If the two senses are out of sync, a person can experience difficulties in academics, social situations and activities such as sports.

Balance between vision and hearing is necessary for a person to learn letter sounds, for example, while applying those sounds to the words they see on a page. In social situations, a person can better understand what another is saying – and meaning — by watching body language and facial expression. Autistic patients cannot discern the nuances of a joke because they simply listen. They do not connect sound and vision, because the environment around them is too confusing.

A student whose eyesight is more sensitive than his or her hearing may be easily distracted by activities and moving objects in the environment and unable to concentrate on what the teacher is saying. People whose peripheral vision is not sufficiently “tuned in” may have to turn their head before finding what is causing a certain sound.

A quantum sensing experiment now has the potential to identify single gravitons — the particles that make up gravity — which was considered impossible until now. A team led by Stevens professor Igor Pikovski has recently proposed a method to detect individual gravitons, believed to be the quantum building blocks of gravity. They suggest that with advancements in quantum technology, this experiment could become a reality in the near future.

We’re joined by Dr. Denis Noble, Professor Emeritus of Cardiovascular Physiology at the University of Oxford, and the father of ‘systems biology’. He is known for his groundbreaking creation of the first mathematical model of the heart’s electrical activity in the 1960s which radically transformed our understanding of the heart.

Dr. Noble’s contributions have revolutionized our understanding of cardiac function and the broader field of biology. His work continues to challenge long-standing biological concepts, including gene-centric views like Neo-Darwinism.

In this episode, Dr. Noble discusses his critiques of fundamental biological theories that have shaped science for over 80 years, such as the gene self-replication model and the Weissmann barrier. He advocates for a more holistic, systems-based approach to biology, where genes, cells, and their environments interact in complex networks rather than a one-way deterministic process.

We dive deep into Dr. Noble’s argument that biology needs to move beyond reductionist views, emphasizing that life is more than just the sum of its genetic code. He explains how AI struggles to replicate even simple biological systems, and how biology’s complexity suggests that life’s logic lies not in DNA alone but in the entire organism.

The conversation covers his thoughts on the flaws of Neo-Darwinism, the influence of environmental factors on evolution, and the future of biology as a field that recognizes the interaction between nature and nurture. We also explore the implications of his work for health and longevity, and how common perspectives on genetics might need rethinking.

All the topics we covered in the episode: