Since 2020, the condition known as long COVID-19 has become a widespread disability affecting the health and quality of life of millions of people across the globe and costing economies billions of dollars in reduced productivity of employees and an overall drop in the work force.

The intense scientific effort that long COVID sparked has resulted in more than 24,000 scientific publications, making it the most researched health condition in any four years of recorded human history.

Long COVID is a term that describes the constellation of long-term health effects caused by infection with the SARS-CoV-2 virus. These range from persistent respiratory symptoms, such as shortness of breath, to debilitating fatigue or brain fog that limits people’s ability to work, and conditions such as heart failure and diabetes, which are known to last a lifetime.

which is widely believed to be the root cause of many age-related diseases.

The study, published today in the journal npj Aging, raises the exciting possibility of a protective agent that could dampen age-related inflammation and restore normal immune function in older adults.

PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was initially identified at the University of Birmingham in 2015. While the role of the PEPITEM pathway has already been demonstrated in immune-mediated diseases, this is the first data showing that PEPITEM has the potential to increase healthspan in an aging population.

PLATO, or PLAnetary Transits and Oscillations of stars, is being built to find nearby potentially habitable worlds around Sun-like stars that we can examine in detail.

The space telescope will blast into orbit on Europe’s new rocket, Ariane-6, which made its maiden flight last week after being developed at a cost of €4billion (£3.4billion).

Dr David Brown, of the University of Warwick, is giving an update on the mission at the Royal Astronomical Society’s National Astronomy Meeting at the University of Hull this week.

New observations reveal neutron stars paired with stars like our Sun. Astronomers have uncovered what appear to be 21 neutron stars in orbit around stars like our Sun. The discovery is surprising because it is not clear how a star that exploded winds up next to a star like our Sun.

Most stars in our universe come in pairs. While our own Sun is a loner, many stars like our Sun orbit similar stars, while a host of other exotic pairings between stars and cosmic orbs pepper the universe. Black holes, for example, are often found orbiting each other. One pairing that has proved to be quite rare is that between a Sun-like star and a type of dead star called a neutron star.

Now, astronomers led by Caltech’s Kareem El-Badry have uncovered what appear to be 21 neutron stars in orbit around stars like our Sun. Neutron stars are dense burned-out cores of massive stars that exploded. On their own, they are extremely faint and usually cannot be detected directly. But as a neutron star orbits around a Sun-like star, it tugs on its companion, causing the star to shift back and forth in the sky. Using the European Space Agency’s Gaia mission, the astronomers were able to catch these telltale wobbles to reveal a new population of dark neutron stars.

A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies.

“There is great interest in reducing senescence to slow or reverse aging or aging-associated diseases. We discovered a noncoding RNA that when inhibited strongly impairs senescence, suggesting that it could be a therapeutic target for conditions associated with aging,” said Joshua Mendell, M.D., Ph.D., Professor of Molecular Biology and a member of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. He is also a Howard Hughes Medical Institute Investigator.

Dr. Mendell led the study with co-first authors Yujing Cheng, Ph.D., a recent graduate of the Genetics, Development, and Disease graduate program; and Siwen Wang, M.D., a former postdoctoral researcher, both in the Mendell Lab.

Astronomers have created the most detailed weather report so far for two distant worlds beyond our own solar system.

The international study — the first of its kind — reveals the extreme atmospheric conditions on the celestial objects, which are swathed in swirling clouds of hot sand amid temperatures of 950C.

Using NASA’s powerful James Webb Space Telescope (JWST), researchers set out to capture the weather on a pair of brown dwarfs — cosmic bodies that are bigger than planets but smaller than stars.

Scientists propose a new way of implementing a neural network with an optical system which could make machine learning more sustainable in the future. The researchers at the Max Planck Institute for the Science of Light have published their new method in Nature Physics, demonstrating a method much simpler than previous approaches.

Machine learning and artificial intelligence are becoming increasingly widespread with applications ranging from computer vision to text generation, as demonstrated by ChatGPT. However, these complex tasks require increasingly complex neural networks; some with many billion parameters. This rapid growth of neural network size has put the technologies on an unsustainable path due to their exponentially growing energy consumption and training times. For instance, it is estimated that training GPT-3 consumed more than 1,000 MWh of energy, which amounts to the daily electrical energy consumption of a small town. This trend has created a need for faster, more energy-and cost-efficient alternatives, sparking the rapidly developing field of neuromorphic computing. The aim of this field is to replace the neural networks on our digital computers with physical neural networks.

Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children’s Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.

The preclinical findings were published in the journal Proceedings of the National Academy of Sciences.

Last year, a multi-institutional consortium of researchers found that the genes of the mitochondria, the energy producers of our cells, can be negatively impacted by the virus, leading to dysfunction in multiple organs beyond the lungs.

A new study finds clues lurking in the Red Planet’s soil. The question of whether Mars ever supported life has captivated the imagination of scientists and the public for decades. Central to the discovery is gaining insight into the past climate of Earth’s neighbor: was the planet warm and wet, with seas and rivers much like those found on our own planet? Or was it frigid and icy, and therefore potentially less prone to supporting life as we know it? A new study finds evidence to support the latter by identifying similarities between soils found on Mars and those of Canada’s Newfoundland, a cold subarctic climate.

The study, published July 7th in Communications Earth and Environment, looked for soils on Earth with comparable materials to Mars’ Gale Crater. Scientists often use soil to depict environmental history, as the minerals present can tell the story of landscape evolution through time. Understanding more about how these materials formed could help answer long-standing questions about historical conditions on the red planet. The soils and rocks of Gale Crater provide a record of Mars’ climate between 3 and 4 billion years ago, during a time of relatively abundant water on the planet — and the same time period that saw life first appear on Earth.

“Gale Crater is a paleo lakebed — there was obviously water present. But what were the environmental conditions when the water was there?” says Anthony Feldman, a soil scientist and geomorphologist now at DRI. “We’re never going to find a direct analog to the Martian surface, because conditions are so different between Mars and Earth. But we can look at trends under terrestrial conditions and use those to try to extrapolate to Martian questions.”

Lithium (Li) secondary batteries, commonly used in electric vehicles, store energy by converting electrical energy to chemical energy and generating electricity to release chemical energy to electrical energy through the movement of Li-ions between a cathode and an anode. These secondary batteries mainly use nickel (Ni) cathode materials due to their high lithium-ion storage capacity. Traditional nickel-based materials have a polycrystalline morphology composed of many tiny crystals which can undergo structural degradation during charging and discharging, significantly reducing their lifespan.

One approach to addressing this issue is to produce the cathode material in a “single-crystal” form. Creating nickel-based cathode materials as single large particles, or “single crystals,” can enhance their structural and chemical stability and durability. It is known that single-crystal materials are synthesized at high temperatures and become rigid. However, the exact process of hardening during synthesis and the specific conditions under which this occurs remain unclear.

To improve the durability of nickel cathode materials for electric vehicles, the researchers focused on identifying a specific temperature, referred to as the “critical temperature,” at which high-quality single-crystal materials are synthesized. They investigated various synthesis temperatures to determine the optimal conditions for forming single crystals in synthesis of a nickel-based cathode material (N884). The team systematically observed the impact of temperature on the material’s capacity and long-term performance.