Researchers from the Department of Energy’s Oak Ridge National Laboratory have developed a new application to increase efficiency in memory systems for high-performance computing.

Rather than allow data to bog down traditional memory systems in supercomputers and impact performance, the team from ORNL, along with researchers from the University of Tennessee, Knoxville, created a framework to manage data more efficiently with memory systems that employ more complex structures. Research papers detailing their work were recently accepted in ACM Transactions on Architecture and Code Optimization and the International Journal of High-Performance Computing Applications.

Working under the Exascale Computing Project, or ECP, a multi-year software research, development and deployment project managed by DOE, ORNL senior computer science researcher Terry Jones and his team titled their work the “ECP Simplified Interface to Complex Memories,” or SICM, Project.

Researchers at the University of Cologne and University Hospital Cologne have determined that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as antibody production, but also cause persistent epigenetic changes in innate immune cells.

The study, “Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages,” led by Professor Dr. Jan Rybniker, who heads the Division of Infectious Diseases at University Hospital Cologne and is a principal investigator at the Center for Molecular Medicine Cologne (CMMC), and Dr. Robert Hänsel-Hertsch, principal investigator at the CMMC, was published in Molecular Systems Biology.

The immune system comprises two immunity strategies: the innate and the acquired (adaptive) immune system. The innate immune system provides general protection from pathogens and must react quickly. The adaptive immune system adapts to new pathogens and is highly specific in its response. Both systems work closely together.

Using the unique infrared sensitivity of NASA’s James Webb Space Telescope, researchers can examine ancient galaxies to probe secrets of the early universe. Now, an international team of astronomers has identified bright hydrogen emission from a galaxy in an unexpectedly early time in the universe’s history. The surprise finding is challenging researchers to explain how this light could have pierced the thick fog of neutral hydrogen that filled space at that time.

The Webb telescope discovered the incredibly distant galaxy JADES-GS-z13-1, observed to exist just 330 million years after the big bang, in images taken by Webb’s NIRCam (Near-Infrared Camera) as part of the James Webb Space Telescope Advanced Deep Extragalactic Survey (JADES). Researchers used the galaxy’s brightness in different infrared filters to estimate its redshift, which measures a galaxy’s distance from Earth based on how its light has been stretched out during its journey through expanding space.

For the first time on a global scale, 20 years of observations on Mars have been condensed into a single study led by Francisco Brasil and Pedro Machado, both researchers from the Faculty of Sciences at the University of Lisbon (CIÊNCIAS ULisboa). This study, an extensive and comprehensive analysis of the red planet’s atmospheric waves, has just been published in the Journal of Geophysical Research: Planets.

Atmospheric waves are “wave-shaped disturbances that travel through the planet’s atmosphere, much like waves moving across the surface of water,” explains the study “Atmospheric Gravity Waves in Mars’ Lower Atmosphere: Nadir Observations From OMEGA/Mars Express Data.”

The researchers focused on this energy, which has a significant impact on the planet’s climate. The data, collected by the Observatoire pour la Minéralogie, l’Eau, les Glaces et l’Activité (OMEGA) from the European Mars Express space mission, served as the foundation for this ambitious analysis.

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

Peter Dempsey, Ph.D., professor of pediatrics– developmental biology in the CU School of Medicine, and Justin Brumbaugh, Ph.D., assistant professor of molecular, cellular, and developmental biology at CU Boulder, recently published a paper in the journal Nature Cell Biology showing the importance of the H3K36 methylation process in regulating plasticity and regeneration in intestinal cells.

“The intestine has an enormous ability to regenerate itself after injury, and it does this through a model of dedifferentiation,” Dempsey explains. “The cells dedifferentiate back into a type of regenerative stem cell after injury, and those stem cells eventually recover the intestine and turn back to normal cells.”

When it comes to early detection of cognitive impairment, a new study suggests that the nose knows. Researchers from Mass General Brigham have developed olfactory tests—in which participants sniff odor labels that have been placed on a card—to assess people’s ability to discriminate, identify and remember odors. They found that participants could successfully take the test at home and that older adults with cognitive impairment scored lower on the test than cognitively normal adults.

Results are published in Scientific Reports.

“Early detection of cognitive impairment could help us identify people who are at risk of Alzheimer’s disease and intervene years before memory symptoms begin,” said senior author Mark Albers, MD, Ph.D., of the Laboratory of Olfactory Neurotranslation, the McCance Center for Brain Health, and Department of Neurology at Massachusetts General Hospital.

Constructed strain achieves record-high yield from methanol, advancing ecofriendly biomanufacturing. Researchers from Osaka Metropolitan University have discovered the ideal genetic “recipe” to turn yeast into a tiny yet powerful eco-friendly factory that converts methanol into D-lactic acid, a key compound used in biodegradable plastics and pharmaceuticals.

This approach could help reduce reliance on petroleum-based processes and contribute to more sustainable chemical production.

Lactic acid is widely used in food, cosmetics, pharmaceuticals and bioplastics.

So-called “memristors” consume extremely little power and behave similarly to brain cells. Researchers from Jülich, led by Ilia Valov, have now introduced novel memristive components that offer significant advantages over previous versions: they are more robust, function across a wider voltage range, and can operate in both analog and digital modes. These properties could help address the problem of “catastrophic forgetting,” where artificial neural networks abruptly forget previously learned information.

The problem of catastrophic forgetting occurs when deep neural networks are trained for a new task. This is because a new optimization simply overwrites a previous one. The brain does not have this problem because it can apparently adjust the degree of synaptic change; something experts call “metaplasticity.”

They suspect that it is only through these different degrees of plasticity that our brain can permanently learn new tasks without forgetting old content. The new memristor accomplishes something similar.

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2). This protein plays an important role in inflammatory and metabolic processes and contributes to cellular homeostasis.

The discovery, described in the Journal of Medicinal Chemistry, could open up new avenues for investigating the biological and pathological functions of the enzyme and provide promising candidates for the development of new drugs.

“Although h15-LOX-2 is a potential biological target, it’s scarcely been explored for this purpose. Our work contributes to new inhibitors that have structural diversity among themselves and with respect to inhibitors already described in the literature. What’s more, they have similar drug properties according to predictions based on computational models,” says Lucas Gasparello Viviani, first author of the article.

A research team has developed the world’s first quantum microsatellite and demonstrated real-time quantum key distribution (QKD) between the satellite and multiple compact, mobile ground stations.

The research, led by Pan Jianwei, Peng Chengzhi, and Liao Shengkai from USTC, jointly with the Jinan Institute of Quantum Technology, Shanghai Institute of Technical Physics, the Innovation Academy for Microsatellites of the Chinese Academy of Sciences, and Stellenbosch University of South Africa, is published in Nature.

Quantum secure communication is fundamental to national information security and socioeconomic development. QKD, a communication method with proven unconditional security, significantly enhances data transmission security. While fiber-based QKD networks have achieved regional implementation, their practical application over long distances remains constrained by signal loss and limited coverage. Satellite-based systems present a viable solution through free-space communication, potentially enabling QKD on a global scale.