7 month treatment, 6 years returned according to a methylation clock, mostly in people who’s biological age was greater than their calendar age.

Dr. Brian Kennedy presents 4 molecules which show promising effects in both healthspan & lifespan in this video. https://pubmed.ncbi.nlm.nih.gov/37289866/http… https://pubmed.ncbi.nlm.nih.gov/37637… https://pubmed.ncbi.nlm.nih.gov/37925… https://pubmed.ncbi.nlm.nih.gov/35584… https://pubmed.ncbi.nlm.nih.gov/35050… https://pubmed.ncbi.nlm.nih.gov/28199… https://pubmed.ncbi.nlm.nih.gov/37904… https://pubmed.ncbi.nlm.nih.gov/37697… https://pubmed.ncbi.nlm.nih.gov/37217… https://pubmed.ncbi.nlm.nih.gov/34952… https://pubmed.ncbi.nlm.nih.gov/34847…

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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #longevity #taurine #supplements #CaAkg #urolithinA #Nicotinamide #ALA #quercetin #EGCG #greentea #vitaminC #zinc #rutin #CD38 #Apigenin #TMG #reverseaging #supplement #slowaging #stayyoung #MethylDonors #Epigenetic #sirtuin #Exercise #NAD #BeingHungry #Rejuvenate #Mitochondria #ALA #Antioxidant #LookYounger #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #aging #Lifespan #Berberine #ReverseAging #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Healthspan #Younger #antiaging #longevity

A quickie about E5.

Dr. Steve Horvath shares some studies on evaluating whether young plasma fraction affects the epigenetic clock and lifespan in this short video.\
https://pubmed.ncbi.nlm.nih.gov/37875…\
https://www.ncbi.nlm.nih.gov/pmc/arti…\
https://pubmed.ncbi.nlm.nih.gov/37500…\
https://www.theguardian.com/science/2…\

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I like the chapter “would you want to be”.

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Ah, immortality, previously only for the gods and individuals with a fetish for chopping each other’s heads off. In more modern times, science is coming closer and closer to both identifying the tapestry of things that cause humans to grow old, and slowly but surely taking the first steps into finding ways to delay and even reverse this process for fun and profit. So, just what causes individuals of the human persuasion to grow old and die, who was the oldest confirmed human, are there any living things that are biologically immortal, and if there was an option to become biologically immortal, would you take it?

0:00 Intro.
3:42 The Oldest Human.
4:50 The Lobster.
9:01 It’s Not the Years Honey, It’s the Mileage.
13:32 Would You Want to Be Biologically Immortal?
17:24 The Senescent Cell Problem.
20:46 A Myriad of Other Factors.
26:04 The Biologically Immortal Creatures.

Author: Daven Hiskey.
Host: Daven Hiskey.
Producer: Daven Hiskey.

This video is #sponsored by ADNTRO.

https://www.youtube.com/watch?v=1-fNggTpGWQ

So if I heard this right, after 8 minutes or so, the effects are temporary and he indicates people would have to take this every couple of years.

Here Akshay talks about his interest in aging, how he met with Dr Katcher and formed Yuvan Research and their experiments with E5 and the results that they saw.
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Chapters.
00:00 Founding of Yuvan.
08:00 What is E5
11:50 How does the effect last?
14:05 How much age reversal.

Links in this video.
Reversal of biological age in multiple rat organs by young porcine plasma fraction.
https://link.springer.com/article/10.1007/s11357-023-00980-6

Akshay Sanghavi is the Chief Executive Officer of Yuvan Research. His work mainly focuses on cell aging, DNA methylation, epigenetics, gene regulation, epigenomics, genomics, regulation of gene expression, and transcriptional regulation.

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Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.

In particular I like the 3D modeling segment.

Here Dr Seranova talks about stem cell use in helping with research into diseases of aging, particularly generating organiods of the brain by growing them from stem cells.
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ProHealth 15% discount Code MODERN : https://prohealth.pxf.io/zNOPoW
NMN http://prohealth.pxf.io/JzQaER
NOVOS Core & Boost https://novos.sjv.io/QyWP7o code 5OFFMHS
DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87
If you would like to support our channel, we’d love a coffee…thank you! _https://www.buymeacoffee.com/mhealthspan_

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN
*Insidetracker* 20% discount Code MODERN20 _https://insidetracker.sjv.io/NkbP7V_
*Bulletproof* 15% off with coupon code: HEALTHSPAN15: _https://tinyurl.com/4npjk5vp_
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*Delavie Sciences* 10% Code Modern Age Defying Serum https://tinyurl.com/yp2jmhy8 Eye Refresh https://tinyurl.com/mt8knv3s.
*OmegaQuant* 5% discount Code MODERN _https://omegaquant.com/shop/_

Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Chapters.
00:00 Clinical trials success rate.
02:10 Aging as a disease.
03:15 Why do clinical trials fail.
05:00 Using stem cells in 3D
09:00 Efficiency of research.
11:45 Organoid formation.

Links in this video.
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels.
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer’s disease by regulating intestinal microbiota.
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.
https://pubmed.ncbi.nlm.nih.gov/28330719/

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Emmett Short discusses these comments on this episode of Lifespan News.

But first, the mad scientist David Sinclair, this time with Peter Diamandis at Abundance 360, giving more details into human trials for the genetic engineering side of the technology versus the chemical and pill side of the technology. Which would you want more? We’ll also hear David’s thoughts on how AI will affect the advancement of this tech. Spoiler: A lot. I’m going to play the best parts and add my commentary along the way.

If you want optimism about life extension, here is Bill Faloon at RAADFest with the latest.

Bill Faloon gave the keynote presentation at the RAADfest conference in September 2023. In his talk, he discussed many of the advances in longevity research over the past year and described the main barrier to faster advances in regenerative medicine.

This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

Cellular senescence is a state of stable cell cycle arrest that can be triggered due to a wide range of extrinsic as well as intrinsic factors. It promotes tissue remodeling, wound repair, and cancer prevention by stopping the proliferation of damaged and aged cells. Senescent cells are characterized by metabolic and morphological alterations, reorganization of the chromatin, and release of pro-inflammatory substances known as the senescence-associated secretory phenotype (SASP) [3]. Irreparable DNA damage, loss of epigenetic information, and telomere shortening are a few factors that can initiate cellular senescence. Accumulation of senescent cells with age results in inflammation as well as the generation of reactive oxygen species (ROS).

A quickie about E5.

Hello, i am back! Blood, sweat and tears have been shed these past months of absence. But enough sweating was done during the summer, tears have already been shed, so that just leaves me with blood. And whether taking a part of blood (plasma) and injecting it into old animals is enough for rejuvenation. That’s right, many of you may remember, earlier this year i made a video on the oldest living rat.- and now we have some updates: in particular, (i) what actually were the rats given, and (ii) what changes were seen, showing both some DNAm and glycan age data.

Find me on Twitter — https://twitter.com/EleanorSheekey.

Support the channel.
through PayPal — https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon — https://www.patreon.com/TheSheekeyScienceShow.

TIMESTAMPS:
Intro and recap — 00:00
New results — 02:45
What were the rats given? — 05:05

References:
https://doi.org/10.1016/j.tcb.2023.01.002 — Extracellular vesicles and nanoparticles: emerging complexities.
Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction — https://doi.org/10.1101/2023.08.06.552148
I took clips of an interview with Dr Harold Katcher from @ModernHealthspan ‘s channel.

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.