In the present investigation, the SD rats were separated into two groups old control group and the treatment group (n = 8). The treatment group received four injections of E5 every alternate day for 8 days, and eight injections every alternate day for 16 days. Body weight, grip strength, cytokines, and biochemical markers were measured for more than 400 days of the study. Clinical observation, necropsy, and histology were performed. The E5 treatment exhibited great potential by showing significantly improved grip strength, remarkably decreased pro-inflammatory markers of chronic inflammation and oxidative stress, as well as biomarkers for vital organs (BUN, SGPT, SGOT, and triglycerides), and increased anti-oxidant levels. Clinical examinations, necropsies, and histopathology revealed that the animals treated with the E5 had normal cellular structure and architecture. In conclusion, this unique ‘plasma-derived exosome’ treatment (E5) alone is adequate to improve the health-span and extend the lifespan of the old SD rats significantly.

Mehmood Khaan opening the Rejuvenation Startup Summit with an outstanding speech on the state of longevity and the groundbreaking work that Hevolution is doing in funding scientists around the globe.

With the Rejuvenation Startup Summit in Berlin the Forever Healthy Foundation produced a great platform for founders and investors to meet and learn from and about eachother.

“If we give it to aged mice, they rejuvenate. If we give it to young mice, they age slower. No other therapy right now can do this.”

The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along.

Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic modifications, these white blood cells can attack another group of cells known as senescent cells. These cells are thought to be responsible for many of the diseases we grapple with later in life.

Senescent cells are those that stop replicating. As we age, they build up in our bodies, resulting in harmful inflammation. While several drugs currently exist that can eliminate these cells, many must be taken repeatedly over time.

Blood plasma from young donors treating age-related conditions (RAADfest 2023)

Retired naval officer Joseph Dituri has spent more than three months living inside a 100sqft pod in the depths of the Atlantic Ocean.

His time spent below the waves was part of a study group to research the effects of a pressurised environment on the human body.

A former intelligence official turned whistleblower has given Congress and the Intelligence Community Inspector General extensive classified information about deeply covert programs that he says possess retrieved intact and partially intact craft of non-human origin.

The information, he says, has been illegally withheld from Congress, and he filed a complaint alleging that he suffered illegal retaliation for his confidential disclosures, reported here for the first time.

Other intelligence officials, both active and retired, with knowledge of these programs through their work in various agencies, have independently provided similar, corroborating information, both on and off the record.

At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.

Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?

Plasma is the yellowish, liquid part of your blood. There is emerging evidence that plasma exchanges may offer various health benefits.

Nervous but excited, we travelled to a transfusion centre in Dallas Texas to make it happen.

WHAT IS BLUEPRINT
I’ve invested millions of dollars building the world’s leading anti-aging protocol, becoming the most measured human in history. Blueprint is an algorithm, built by science, that takes better care of me than I can myself.

And it’s available to you for free. Check out the Blueprint website for recipes, exercise, and other protocols. Become the next evolution of human.

Experience tells us that it is much easier to extend median lifespan than maximum lifespan. Katcher’s trial of E5 in 8 rats breaks this expectation. The last of Harold Katcher’s rats has died, and she outlived her sisters by 7 months.

FREE WEBINAR: https://draronica.com/free-webinar/

In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.

This interview is a must watch for everyone who wants to develop a critical stance toward the field of longevity research and balance enthusiasm with evidence.

I hope you enjoy this interview!

TIMESTAMPS
00:00 Introduction.
04:33 Definitions: Aging, lifespan, healthspan.
09:08 What is biohacking.
14:56 The Dog Aging project.
19:39 Rapamycin: Longevity effects in mice.
22:28 Can rapamycin impair muscle growth? Is it in contraindicated for people who want to build muscle mass?
27:09 Exercise, inhibition of mTor, and rationale for cycling rapamycin and exercise.
29:46 Getting around the growth vs. resilience tradeoff in longevity.
32:00 Epigenetic clocks: Hope vs. hype.
32:43 Best functional markers of longevity.
36:30 Sterile inflammation, auto-immunity, and immune senescence.
40:24 The best and worst longevity supplements for Matt Kaeberlein.
45:50 What longevity hacks Matt implements in his own life.
48:00 Lucia’s and Matt’s thoughts on calorie restriction for longevity.
50:30 How can people discriminate between science and sneak oil?

The Dog Aging project: https://dogagingproject.org/

“The inevitability of death is what makes life worth living.” — Henry.

“Would we need to extend the years everyone should continue to be in the workforce, in order to pay for those not contributing?” — Marianne.

“Imagine you have people with all the prejudices they grew up with and they never die. Or you have someone who is a dictator and they get to live forever and be dictator forever. Or you have Congress where you have 80 and 90 year olds holding office forever but now they never die so nobody new can take over.” — Avram.