Blood plasma from young donors treating age-related conditions (RAADfest 2023)

Retired naval officer Joseph Dituri has spent more than three months living inside a 100sqft pod in the depths of the Atlantic Ocean.

His time spent below the waves was part of a study group to research the effects of a pressurised environment on the human body.

A former intelligence official turned whistleblower has given Congress and the Intelligence Community Inspector General extensive classified information about deeply covert programs that he says possess retrieved intact and partially intact craft of non-human origin.

The information, he says, has been illegally withheld from Congress, and he filed a complaint alleging that he suffered illegal retaliation for his confidential disclosures, reported here for the first time.

Other intelligence officials, both active and retired, with knowledge of these programs through their work in various agencies, have independently provided similar, corroborating information, both on and off the record.

At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.

Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?

Plasma is the yellowish, liquid part of your blood. There is emerging evidence that plasma exchanges may offer various health benefits.

Nervous but excited, we travelled to a transfusion centre in Dallas Texas to make it happen.

WHAT IS BLUEPRINT
I’ve invested millions of dollars building the world’s leading anti-aging protocol, becoming the most measured human in history. Blueprint is an algorithm, built by science, that takes better care of me than I can myself.

And it’s available to you for free. Check out the Blueprint website for recipes, exercise, and other protocols. Become the next evolution of human.

Experience tells us that it is much easier to extend median lifespan than maximum lifespan. Katcher’s trial of E5 in 8 rats breaks this expectation. The last of Harold Katcher’s rats has died, and she outlived her sisters by 7 months.

FREE WEBINAR: https://draronica.com/free-webinar/

In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.

This interview is a must watch for everyone who wants to develop a critical stance toward the field of longevity research and balance enthusiasm with evidence.

I hope you enjoy this interview!

TIMESTAMPS
00:00 Introduction.
04:33 Definitions: Aging, lifespan, healthspan.
09:08 What is biohacking.
14:56 The Dog Aging project.
19:39 Rapamycin: Longevity effects in mice.
22:28 Can rapamycin impair muscle growth? Is it in contraindicated for people who want to build muscle mass?
27:09 Exercise, inhibition of mTor, and rationale for cycling rapamycin and exercise.
29:46 Getting around the growth vs. resilience tradeoff in longevity.
32:00 Epigenetic clocks: Hope vs. hype.
32:43 Best functional markers of longevity.
36:30 Sterile inflammation, auto-immunity, and immune senescence.
40:24 The best and worst longevity supplements for Matt Kaeberlein.
45:50 What longevity hacks Matt implements in his own life.
48:00 Lucia’s and Matt’s thoughts on calorie restriction for longevity.
50:30 How can people discriminate between science and sneak oil?

The Dog Aging project: https://dogagingproject.org/

“The inevitability of death is what makes life worth living.” — Henry.

“Would we need to extend the years everyone should continue to be in the workforce, in order to pay for those not contributing?” — Marianne.

“Imagine you have people with all the prejudices they grew up with and they never die. Or you have someone who is a dictator and they get to live forever and be dictator forever. Or you have Congress where you have 80 and 90 year olds holding office forever but now they never die so nobody new can take over.” — Avram.

Dr. Harold Katcher, Cheif Scientific Officer of Yuvan Research Inc., is interviewed by Nicolás Cherñavsky and Nina Torres Zanvettor about the rat Sima, a Sprague Dawley rat that has lived for 47 months (exceeding the maximum lifespan of 45.5 months of this rat strain) thanks to a treatment with E5, a plasma-based therapeutic developed by Yuvan.

#Sima #SpragueDawley #47months #HaroldKatcher #Yuvan #E5 #plasma

Bryan Johnson releases his rejuvenation protocol:

Blueprint is a public science experiment to determine whether it’s possible to stay the same biological age. This requires slowing down aging processes as much as possible and then reversing the aging that has happened. Currently my speed of aging is .76 (DunedinPACE). That means for every 365 days each year, I age 277 days. My goal is to remain the same age biologically for every 365 days that pass.

I openly share (for free!) my diet, exercise and other protocols so that others can benefit and try to improve upon what I’m doing. I also openly share my health data as data is better than human opinion at guiding decision making. You can find everything here: https://blueprint.bryanjohnson.co/

This video is a whirlwind tour of what my daily life looks like as my team and I are on this adventure.

On the surface, Blueprint may seem like something about health, wellness and aging. To me, it’s a philosophy.

Blueprint was born when years ago I would overeat every night as a result of the stress of everyday life: being a startup entrepreneur, a father to three young kids, leaving a religion I was born into, chronic depression etc… Every night, at 7 PM, there was nothing I could do to stop myself from committing this self-harm of overeating. This was rapidly degrading my health and wellness and speeding up my pace of aging. Eventually, I playfully fired ‘Evening Bryan’, and revoked his decision making authority from 7 PM — 10 PM every night.

I imagine a future where we would not accept self-harm as the norm. The idea of systematically and reliably avoiding self-harm may be one of the most important goals of the 21st century. How silly is it that we do things, individually and collectively that harm our self interests? How odd is it that we are so normalized to it that we even cheer it on?

Our best selves, and a positive shared future, may start with this simple principle. Blueprint is the plan for that.

This video was recorded at the Foresight Vision Weekend 2022 at Château du Feÿ in France.

Michael Greve | Longevity Investing.

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