While aging is inevitable, it’s a process that many people would like to slow. Here are 12 of the best anti-aging supplements.

The research, published last month in the journal eLife, suggests that the drug candidates may be useful for treating a broader array of conditions and points out a new pathway that links normal aging to Alzheimer’s disease.

“This study further validated these two compounds not only as Alzheimer’s drug candidates but also as potentially more widely useful for their anti-aging effects,” says Pamela Maher, a senior staff scientist at Salk and a co-corresponding author of the new paper.

Early in the development of Alzheimer’s disease, the brain becomes over excited, potentially through the loss of inhibitory, or GABAergic, interneurons that keep other neurons from signaling too much. Because interneurons require more energy compared to other neurons, they may be more susceptible to dying when they encounter the Alzheimer’s disease protein amyloid beta. Amyloid beta has been shown to damage mitochondria — the metabolic engine for cells — by interfering with SIRT3, a protein that preserves mitochondrial functions and protects neurons.

Cheng et al. genetically reduced levels of SIRT3 in mouse models of Alzheimer’s disease. Mice with low levels of SIRT3 experienced a much higher mortality rate, more violent seizures, and increased interneuron death compared to the mice from the standard Alzheimer’s disease model and control mice. However, the mice with reduced levels of SIRT3 experienced fewer seizures and were less likely to die when they ate a diet rich in ketones, a specific type of fatty acid. The diet also increased levels of SIRT3 in the mice.

For a core of longevity true believers, the time to intervene is now.

“How old are you?” James Clement wanted to know.

I turn 50 this year. There’s a new creaking in my bones; my skin doesn’t snap back the way it used to. It’s developed a dull thickness—you can’t tickle me at all. My gums are packing it in and retreating toward my jaw. These changes have been gradual or inexplicably sudden, like the day when I could no longer see the typed words that are my profession. Presbyopia, the ophthalmologist told me. Totally normal. You’re middle-aged.

To Clement, though, my age was great news. “Yep, you are going to live forever,” he said. “I think anybody under 50 who does not have a genetic liability will make it to longevity escape velocity.”

Internal Medicine Article: Statin use over 65 years of age and all-cause mortality: A 10-year follow-up of 19,518 people.

I’m a actually really excited because I have a special surprise for everyone. Remember last year when I gave away all those stabs for free? This is even better.

How much better? I’m willing to smack a bunch of their links into my post here.

BTW, it’s in Vegas. I mean… C’mon.

I cannot say that I am cured, but this might be something really interesting.

Dr Grace Gosar began following a medication and diet programme devised by a Staffordshire scientist.

We found that eating one cup of blueberries per day resulted in sustained improvements in vascular function and arterial stiffness—making enough of a difference to reduce the risk of cardiovascular disease by between 12 and 15 percent.

Eating a cup of blueberries a day reduces risk factors for cardiovascular disease—according to new research led by the University of East Anglia, in collaboration with colleagues from Harvard and across the UK.

New findings published today in the American Journal of Clinical Nutrition show that eating 150g of blueberries daily reduces the risk of cardiovascular disease by up to 15 percent.

The research team from UEA’s Department of Nutrition and Preventive Medicine, Norwich Medical School, say that blueberries and other berries should be included in dietary strategies to reduce the risk of cardiovascular disease—particularly among at risk groups.

Huge.

The solvent-based method could be much cheaper to use than reverse osmosis or distillation based on water evaporating.

Neurodegenerative diseases like multiple sclerosis (MS) affect millions of people worldwide and occur when parts of the nervous system lose function over time. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that a type of skin-related stem cell could be used to help regenerate myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders.

The discovery into these types of stem cells is significant because they could offer a simpler and less invasive alternative to using embryonic stem cells. This early stage research showed that by using these skin-related stem cells, researchers were able to restore myelin sheath formation in mice.

“This research enhances the possibility of identifying human skin stem cells that can be isolated, expanded, and used therapeutically. In the future, we plan to continue our research in this area by determining whether these cells can enhance functional recovery from neuronal injury,” said Thomas J. Hornyak, MD, PhD, Associate Professor and Chairman of the Department of Dermatology, and Principal Investigator in this research. “In the future, we plan to continue our research in this area by determining whether these cells can enhance functional recovery from neuronal injury.”