A supermassive black hole in the center of the Milky Way galaxy is creating a light show that’s intriguing astronomers.

Flares of light have been observed in a disk orbiting the black hole Sagittarius A*, according to a team of astrophysicists studying the black hole who published their findings Tuesday in The Astrophysical Journal Letters. Known as an accretion disk, it’s hot, contains a steady flow of materials like gas or plasma, and flickers constantly. The disks emit light that can be detected using infrared and X-ray instruments, which helps astronomers better observe the black holes the disks orbit.

Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine anti-aging interventions produce lower levels of pro-inflammatory proteins. Here, we explore the hypothesis that different longevity interventions diminish NF-κB levels, potentially mediating some of the anti-inflammatory benefits of lifespan-extending interventions. We found that the NF-κB protein p65 is significantly downregulated in the liver of several kinds of slow-aging mice. These included both sexes of GHRKO and Snell Dwarf mutant mice, and in females only of PAPPA KO mice. P65 is also lower in both sexes of mice treated with rapamycin, canagliflozin, meclizine, or acarbose, and in mice undergoing caloric restriction. Two drugs that extend lifespan of male mice, i.e. 17α-estradiol and astaxanthin, however, did not produce lower levels of p65.

Lenacapavir, a twice yearly injection that prevents HIV transmission, was named the breakthrough medicine of 2024. But without US foreign aid dollars, its delivery to millions worldwide is under threat.

Since their invention, traditional computers have almost always relied on semiconductor chips that use binary “bits” of information represented as strings of 1’s and 0’s. While these chips have become increasingly powerful and simultaneously smaller, there is a physical limit to the amount of information that can be stored on this hardware. Quantum computers, by comparison, utilize “qubits” (quantum bits) to exploit the strange properties exhibited by subatomic particles, often at extremely cold temperatures.

Two qubits can hold four values at any given time, with more qubits translating to an exponential increase in calculating capabilities. This allows a quantum computer to process information at speeds and scales that make today’s supercomputers seem almost antiquated. Last December, for example, Google unveiled an experimental quantum computer system that researchers say takes just five minutes to finish a calculation that would take most supercomputers over 10 septillion years to complete—longer than the age of the universe as we understand it.

But Google’s Quantum Processing Unit (QPU) is based on different technology than Microsoft’s Majorana 1 design, detailed in a paper published on February 19 in the journal Nature. The result of over 17 years of design and research, Majorana 1 relies on what the company calls “topological qubits” through the creation of topological superconductivity, a state of matter previously conceptualized but never documented.

In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.

In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in a surgical context.

From parabiosis experiments to the clinic.

Startup lands $17m to advance noninvasive approach where nanoparticles act as ‘antennae’ to communicate signals in and out of the brain.

Luckily “false vacuum decay” would take millions of years to occur, if it happens at all.

Once, rivers flowed on the Red Planet under a thick atmosphere, until 3 billion years ago both disappeared. Now, scientists are close to finding where Mars’s missing atmosphere and water went.

A new understanding of our relationship with our ‘friendly’ gut microbes shows they actually have a dark side and help cause ageing. Here’s how to fight back.