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Archive for the ‘chemistry’ category: Page 15

Nov 11, 2023

Revolutionizing CRISPR: Quantum Biology and AI Merge to Enhance Genome Editing

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics, quantum physics, robotics/AI

Oak Ridge National Laboratory’s research in quantum biology and AI has significantly improved the efficiency of CRISPR Cas9 genome editing in microbes, aiding in renewable energy development.

Scientists at Oak Ridge National Laboratory (ORNL) used their expertise in quantum biology, artificial intelligence, and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

CRISPR is a powerful tool for bioengineering, used to modify genetic code to improve an organism’s performance or to correct mutations. The CRISPR Cas9 tool relies on a single, unique guide RNA.

Nov 11, 2023

At least 491 dangerous chemicals found in recycled plastics

Posted by in categories: chemistry, energy, sustainability

“Plastic recycling has been touted as a solution to the plastics pollution crisis, but toxic chemicals in plastics complicate their reuse and disposal and hinder recycling.”


As such, plastic recycling today is an essential part of waste management and environmental preservation initiatives. Recycling plastics minimizes the environmental impact of plastic manufacturing, conserves energy, and helps lower the need for new raw materials.

A crucial sustainable process

Continue reading “At least 491 dangerous chemicals found in recycled plastics” »

Nov 10, 2023

Study reveals bacterial protein capable of keeping human cells healthy

Posted by in categories: biotech/medical, chemistry, life extension

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells’ biochemical reactions.

The study is published in the journal PNAS. The researchers analyzed more than 130 proteins released by Coxiella burnetii when this bacterium invades host cells, and found at least one to be capable of prolonging cell longevity by acting directly on mitochondria.

After invading host cells, C. burnetii releases a hitherto unknown protein, which the authors call mitochondrial coxiella effector F (MceF). MceF interacts with glutathione peroxidase 4 (GPX4), an anti-oxidant enzyme located in the mitochondria, to improve mitochondrial function by promoting an anti-oxidizing effect that averts cell damage and death, which may occur when pathogens replicate inside .

Nov 9, 2023

Photonics team develops high-performance ultrafast lasers that fit on a fingertip

Posted by in categories: biological, chemistry, computing, transportation

Lasers are essential tools for observing, detecting, and measuring things in the natural world that we can’t see with the naked eye. But the ability to perform these tasks is often restricted by the need to use expensive and large instruments.

In a newly published cover-story paper in the journal Science, researcher Qiushi Guo demonstrates a novel approach for creating high-performance ultrafast lasers on nanophotonic chips. His work centers on miniaturizing mode-lock lasers—a unique laser that emits a train of ultrashort, coherent light pulses in femtosecond intervals, which is an astonishing quadrillionth of a second.

Ultrafast mode-locked lasers are indispensable to unlocking the secrets of the fastest timescales in nature, such as the making or breaking of molecular bonds during chemical reactions, or light propagation in a turbulent medium. The high-speed, pulse-peak intensity and broad-spectrum coverage of mode-locked lasers have also enabled numerous photonics technologies, including optical atomic clocks, biological imaging, and computers that use light to calculate and process data.

Nov 9, 2023

Deep-sea sniffer dog? Scientists develop device to detect new molecules

Posted by in categories: biotech/medical, chemistry

The system shows potential for drug development in delicate environments such as coral reefs.


ACS

To better comprehend this, researchers have presented a proof-of-concept device that “sniffs” seawater, capturing dissolved chemicals for analysis. The underwater device “catches and concentrates dissolved substances generated by sponges or other marine animals while causing no damage to the source or the environment,” said a statement.

Continue reading “Deep-sea sniffer dog? Scientists develop device to detect new molecules” »

Nov 9, 2023

Huge Texas chemical blast prompts stay-at-home order

Posted by in categories: chemistry, education

One person is injured after glue factory explosion, which sparked school evacuations and road closures.

Nov 9, 2023

Teaching AI systems to use intuition to find new medicines

Posted by in categories: biotech/medical, chemistry, robotics/AI

A combined team of biomedical researchers from Novartis Institutes for Biomedical Research and Microsoft Research AI4Science has made inroads into teaching AI systems how to find new medicines. In their study, reported in the journal Nature Communications, the group used feedback from chemists in the field to provide intuition guidelines for an AI model.

Finding is a notoriously difficult and laborious task. The process for finding new therapies typically involves experts in a variety of fields working on different parts of the problem. Doctors and other medical researchers, for example, must first uncover the roots of a given illness to find its cause. Chemists or other must then find a chemical that might reverse the problem or stop it from happening in the first place.

Both parts of the process take time and effort. In this new project, the research team sought to determine whether AI applications might make the second part easier.

Nov 9, 2023

Scientists use quantum biology, AI to sharpen genome editing tool

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics, quantum physics, robotics/AI

Scientists at Oak Ridge National Laboratory have used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

CRISPR is a powerful tool for bioengineering, used to modify to improve an organism’s performance or to correct mutations. The CRISPR Cas9 tool relies on a single, unique guide RNA that directs the Cas9 enzyme to bind with and cleave the corresponding targeted site in the genome.

Existing models to computationally predict effective guide RNAs for CRISPR tools were built on data from only a few model species, with weak, inconsistent efficiency when applied to microbes.

Nov 8, 2023

How frozen baby corals and high-powered lasers could help dying reefs

Posted by in categories: chemistry, nanotechnology

In 2018, researchers reported that they had managed to get a coral larva to survive freezing and thawing for the first time. The scientists had added gold nanoparticles to their antifreeze to help the corals warm evenly during reheating. However, the thawed larvae were unable to settle and develop into adults. Instead, they kept swimming until they died.

When Narida began her experiments with hood corals in 2021, she included gold in her antifreeze recipe and combined several different antifreeze chemicals to reduce the solution’s toxicity. To thaw the animals quickly and minimize damage, Narida used a high-powered laser designed for welding jewelry. Then, she carefully washed the antifreeze away with seawater, rehydrating the corals. In the end, a whopping 11 percent of larvae in the experiment survived thawing, then settled, and developed into adults.

Leandro Godoy, a coral cryobiologist at the Federal University of Rio Grande do Sul in Brazil, is impressed by how many larvae survived after settling. “It’s a huge step,” he says, considering that, in the wild, only about five percent of corals make it that far.

Nov 7, 2023

New antibody could target breast cancers

Posted by in categories: biotech/medical, chemistry

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks. With further development, the antibody might offer an effective drug treatment for those same breast cancers.

The new antibody targets an enzyme called PTPRD that is overabundant in some breast cancers. PTPRD belongs to a family of known as protein tyrosine phosphatases (PTPs), which help regulate many cellular processes. They do this by working in concert with enzymes called to control how other proteins inside cells behave. Kinases add small chemical regulators called phosphates to proteins. PTPs take them off.

Disruptions in the addition or removal of phosphates can contribute to inflammation, diabetes, and . Some disruptions can be corrected with kinase-blocking drugs.

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